Search Results
Overview
| Uniprot ID | Q9BRK4 |
|---|---|
| Protein Name | Leucine zipper putative tumor suppressor 2 |
| Gene Name | LZTS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 280 | SGRSSSSKSTGSLGG |
Function
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin
Protein Sequence
10
MAIVQTLPVP
20
LEPAPEAATA
30
PQAPVMGSVS
40
SLISGRPCPG
50
GPAPPRHHGP
60
PGPTFFRQQD
70
GLLRGGYEAQ
80
EPLCPAVPPR
90
KAVPVTSFTY
100
INEDFRTESP
110
PSPSSDVEDA
120
REQRAHNAHL
130
RGPPPKLIPV
140
SGKLEKNMEK
150
ILIRPTAFKP
160
VLPKPRGAPS
170
LPSFMGPRAT
180
GLSGSQGSLT
190
QLFGGPASSS
200
SSSSSSSAAD
210
KPLAFSGWAS
220
GCPSGTLSDS
230
GRNSLSSLPT
240
YSTGGAEPTT
250
SSPGGHLPSH
260
GSGRGALPGP
270
ARGVPTGPSH
280
SDSGRSSSSK
290
STGSLGGRVA
300
GGLLGSGTRA
310
SPDSSSCGER
320
SPPPPPPPPS
330
DEALLHCVLE
340
GKLRDREAEL
350
QQLRDSLDEN
360
EATMCQAYEE
370
RQRHWQRERE
380
ALREDCAAQA
390
QRAQRAQQLL
400
QLQVFQLQQE
410
KRQLQDDFAQ
420
LLQEREQLER
430
RCATLEREQR
440
ELGPRLEETK
450
WEVCQKSGEI
460
SLLKQQLKES
470
QAELVQKGSE
480
LVALRVALRE
490
ARATLRVSEG
500
RARGLQEAAR
510
ARELELEACS
520
QELQRHRQEA
530
EQLREKAGQL
540
DAEAAGLREP
550
PVPPATADPF
560
LLAESDEAKV
570
QRAAAGVGGS
580
LRAQVERLRV
590
ELQRERRRGE
600
EQRDSFEGER
610
LAWQAEKEQV
620
IRYQKQLQHN
630
YIQMYRRNRQ
640
LEQELQQLSL
650
ELEARELADL
660
GLAEQAPCIC
LEEITATEI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0031982 | vesicle |
| Biological Process | GO:0051013 | microtubule severing |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0051168 | nuclear export |
| Biological Process | GO:0051255 | spindle midzone assembly |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
PMID: N/A