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Overview

Uniprot IDQ9BRP0
Protein NameTranscription factor Ovo-like 2
Gene NameOVOL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
3 *****MPKVFLVKRR

Function

Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity)

Protein Sequence

10 MPKVFLVKRR 20 SLGVSVRSWD 30 ELPDEKRADT 40 YIPVGLGRLL 50 HDPPEDCRSD 60 GGSSSGSGSS 70 SAGEPGGAES 80 SSSPHAPESE 90 TPEPGDAEGP 100 DGHLATKQRP 110 VARSKIKFTT 120 GTCSDSVVHS 130 CDLCGKGFRL 140 QRMLNRHLKC 150 HNQVKRHLCT 160 FCGKGFNDTF 170 DLKRHVRTHT 180 GIRPYKCNVC 190 NKAFTQRCSL 200 ESHLKKIHGV 210 QQQYAYKQRR 220 DKLYVCEDCG 230 YTGPTQEDLY 240 LHVNSAHPGS 250 SFLKKTSKKL 260 AALLQGKLTS 270 AHQENTSLSE EEERK

Gene Ontology

Classification GO ID Description
Biological Process GO:0010944 negative regulation of transcription by competitive promoter binding
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0009913 epidermal cell differentiation
Biological Process GO:0010719 negative regulation of epithelial to mesenchymal transition
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045617 negative regulation of keratinocyte differentiation
Biological Process GO:0045746 negative regulation of Notch signaling pathway
Biological Process GO:0060392 negative regulation of SMAD protein signal transduction
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0070351 negative regulation of white fat cell proliferation
Biological Process GO:0090336 positive regulation of brown fat cell differentiation
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0045616 regulation of keratinocyte differentiation
Biological Process GO:0010837 regulation of keratinocyte proliferation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.