Search Results
Overview
| Uniprot ID | Q9BRR0 |
|---|---|
| Protein Name | Zinc finger protein with KRAB and SCAN domains 3 |
| Gene Name | ZKSCAN3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 276 | LPEKEHGKISCHLRE |
Function
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas
Protein Sequence
10
MARELSESTA
20
LDAQSTEDQM
30
ELLVIKVEEE
40
EAGFPSSPDL
50
GSEGSRERFR
60
GFRYPEAAGP
70
REALSRLREL
80
CRQWLQPEMH
90
SKEQILELLV
100
LEQFLTILPG
110
NLQSWVREQH
120
PESGEEVVVL
130
LEYLERQLDE
140
PAPQVSGVDQ
150
GQELLCCKMA
160
LLTPAPGSQS
170
SQFQLMKALL
180
KHESVGSQPL
190
QDRVLQVPVL
200
AHGGCCREDK
210
VVASRLTPES
220
QGLLKVEDVA
230
LTLTPEWTQQ
240
DSSQGNLCRD
250
EKQENHGSLV
260
SLGDEKQTKS
270
RDLPPAEELP
280
EKEHGKISCH
290
LREDIAQIPT
300
CAEAGEQEGR
310
LQRKQKNATG
320
GRRHICHECG
330
KSFAQSSGLS
340
KHRRIHTGEK
350
PYECEECGKA
360
FIGSSALVIH
370
QRVHTGEKPY
380
ECEECGKAFS
390
HSSDLIKHQR
400
THTGEKPYEC
410
DDCGKTFSQS
420
CSLLEHHRIH
430
TGEKPYQCSM
440
CGKAFRRSSH
450
LLRHQRIHTG
460
DKNVQEPEQG
470
EAWKSRMESQ
480
LENVETPMSY
490
KCNECERSFT
500
QNTGLIEHQK
510
IHTGEKPYQC
520
NACGKGFTRI
530
SYLVQHQRSH
VGKNILSQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0007040 | lysosome organization |
| Biological Process | GO:0010507 | negative regulation of autophagy |
| Biological Process | GO:2000773 | negative regulation of cellular senescence |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.