Overview
| Uniprot ID | Q9BRS2 |
|---|
| Protein Name | Serine/threonine-protein kinase RIO1 |
|---|
| Gene Name | RIOK1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 134 |
VTDSVINKVTEKSRQ |
| 236 |
RFRHGYCKGNPRKMV |
| 522 |
GDHARPKKHTTDPDI |
| 81 |
EGVGKLAKGYVWNGG |
Function
Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503)
Protein Sequence
10
MDYRRLLMSR
20
VVPGQFDDAD
30
SSDSENRDLK
40
TVKEKDDILF
50
EDLQDNVNEN
60
GEGEIEDEEE
70
EGYDDDDDDW
80
DWDEGVGKLA
90
KGYVWNGGSN
100
PQANRQTSDS
110
SSAKMSTPAD
120
KVLRKFENKI
130
NLDKLNVTDS
140
VINKVTEKSR
150
QKEADMYRIK
160
DKADRATVEQ
170
VLDPRTRMIL
180
FKMLTRGIIT
190
EINGCISTGK
200
EANVYHASTA
210
NGESRAIKIY
220
KTSILVFKDR
230
DKYVSGEFRF
240
RHGYCKGNPR
250
KMVKTWAEKE
260
MRNLIRLNTA
270
EIPCPEPIML
280
RSHVLVMSFI
290
GKDDMPAPLL
300
KNVQLSESKA
310
RELYLQVIQY
320
MRRMYQDARL
330
VHADLSEFNM
340
LYHGGGVYII
350
DVSQSVEHDH
360
PHALEFLRKD
370
CANVNDFFMR
380
HSVAVMTVRE
390
LFEFVTDPSI
400
THENMDAYLS
410
KAMEIASQRT
420
KEERSSQDHV
430
DEEVFKRAYI
440
PRTLNEVKNY
450
ERDMDIIMKL
460
KEEDMAMNAQ
470
QDNILYQTVT
480
GLKKDLSGVQ
490
KVPALLENQV
500
EERTCSDSED
510
IGSSECSDTD
520
SEEQGDHARP
530
KKHTTDPDID
540
KKERKKMVKE
550
AQREKRKNKI
560
PKHVKKRKEK
TAKTKKGK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0034708 |
methyltransferase complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0030688 |
preribosome, small subunit precursor |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0030490 |
maturation of SSU-rRNA |
| Biological Process |
GO:2000234 |
positive regulation of rRNA processing |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.