Search Results

Overview

Uniprot ID	Q9BRX5
Protein Name	DNA replication complex GINS protein PSF3
Gene Name	GINS3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
207	SNLVQNYKKRKFTDM
208	NLVQNYKKRKFTDME
210	VQNYKKRKFTDMED*

Function

Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293, PubMed:35603789). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)

Protein Sequence

10 MSEAYFRVES 20 GALGPEENFL 30 SLDDILMSHE 40 KLPVRTETAM 50 PRLGAFFLER 60 SAGAETDNAV 70 PQGSKLELPL 80 WLAKGLFDNK 90 RRILSVELPK 100 IYQEGWRTVF 110 SADPNVVDLH 120 KMGPHFYGFG 130 SQLLHFDSPE 140 NADISQSLLQ 150 TFIGRFRRIM 160 DSSQNAYNED 170 TSALVARLDE 180 MERGLFQTGQ 190 KGLNDFQCWE 200 KGQASQITAS 210 NLVQNYKKRK FTDMED

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071162	CMG complex
Cellular Component	GO:0000811	GINS complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Biological Process	GO:0006260	DNA replication
Biological Process	GO:0006270	DNA replication initiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.