Search Results
Overview
| Uniprot ID | Q9BRX8 |
|---|---|
| Protein Name | Peroxiredoxin-like 2A |
| Gene Name | PRXL2A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | IFLDEKKKFYGPQRR |
Function
Involved in redox regulation of the cell (PubMed:19951071, PubMed:26438880). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880)
Protein Sequence
10
MSFLQDPSFF
20
TMGMWSIGAG
30
ALGAAALALL
40
LANTDVFLSK
50
PQKAALEYLE
60
DIDLKTLEKE
70
PRTFKAKELW
80
EKNGAVIMAV
90
RRPGCFLCRE
100
EAADLSSLKS
110
MLDQLGVPLY
120
AVVKEHIRTE
130
VKDFQPYFKG
140
EIFLDEKKKF
150
YGPQRRKMMF
160
MGFIRLGVWY
170
NFFRAWNGGF
180
SGNLEGEGFI
190
LGGVFVVGSG
200
KQGILLEHRE
210
KEFGDKVNLL
220
SVLEAAKMIK
PQTLASEKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0016209 | antioxidant activity |
| Biological Process | GO:0045670 | regulation of osteoclast differentiation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.