Search Results

Overview

Uniprot IDQ9BS26
Protein NameEndoplasmic reticulum resident protein 44
Gene NameERP44
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
140 ADYIRQQKSDPIQEI
170 IIGYFEQKDSDNYRV
303 FLHADCDKFRHPLLH
345 VLIPGKLKQFVFDLH
355 VFDLHSGKLHREFHH

Function

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:14517240, PubMed:29858230). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230)

Protein Sequence

10 MHPAVFLSLP 20 DLRCSLLLLV 30 TWVFTPVTTE 40 ITSLDTENID 50 EILNNADVAL 60 VNFYADWCRF 70 SQMLHPIFEE 80 ASDVIKEEFP 90 NENQVVFARV 100 DCDQHSDIAQ 110 RYRISKYPTL 120 KLFRNGMMMK 130 REYRGQRSVK 140 ALADYIRQQK 150 SDPIQEIRDL 160 AEITTLDRSK 170 RNIIGYFEQK 180 DSDNYRVFER 190 VANILHDDCA 200 FLSAFGDVSK 210 PERYSGDNII 220 YKPPGHSAPD 230 MVYLGAMTNF 240 DVTYNWIQDK 250 CVPLVREITF 260 ENGEELTEEG 270 LPFLILFHMK 280 EDTESLEIFQ 290 NEVARQLISE 300 KGTINFLHAD 310 CDKFRHPLLH 320 IQKTPADCPV 330 IAIDSFRHMY 340 VFGDFKDVLI 350 PGKLKQFVFD 360 LHSGKLHREF 370 HHGPDPTDTA 380 PGEQAQDVAS 390 SPPESSFQKL 400 APSEYRYTLL RDRDEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0035580 specific granule lumen
Molecular Function GO:0003756 protein disulfide isomerase activity
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0009100 glycoprotein metabolic process
Biological Process GO:0006457 protein folding
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0006986 response to unfolded protein

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.