Search Results
Overview
| Uniprot ID | Q9BS40 |
|---|---|
| Protein Name | Latexin |
| Gene Name | LXN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | MVKIQTVKQVQRNDD |
| 36 | HRVFEVQKVKQASME |
| 38 | VFEVQKVKQASMEDI |
Function
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation
Protein Sequence
10
MEIPPTNYPA
20
SRAALVAQNY
30
INYQQGTPHR
40
VFEVQKVKQA
50
SMEDIPGRGH
60
KYHLKFAVEE
70
IIQKQVKVNC
80
TAEVLYPSTG
90
QETAPEVNFT
100
FEGETGKNPD
110
EEDNTFYQRL
120
KSMKEPLEAQ
130
NIPDNFGNVS
140
PEMTLVLHLA
150
WVACGYIIWQ
160
NSTEDTWYKM
170
VKIQTVKQVQ
180
RNDDFIELDY
190
TILLHNIASQ
200
EIIPWQMQVL
210
WHPQYGTKVK
220
HNSRLPKEVQ
LE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0008191 | metalloendopeptidase inhibitor activity |
| Biological Process | GO:0006954 | inflammatory response |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.