Search Results
Overview
| Uniprot ID | Q9BSD7 |
|---|---|
| Protein Name | Cancer-related nucleoside-triphosphatase |
| Gene Name | NTPCR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 165 | IRNRKDVKVFNVTKE |
| 73 | GLEPPPGKRECRVGQ |
Function
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency
Protein Sequence
10
MARHVFLTGP
20
PGVGKTTLIH
30
KASEVLKSSG
40
VPVDGFYTEE
50
VRQGGRRIGF
60
DVVTLSGTRG
70
PLSRVGLEPP
80
PGKRECRVGQ
90
YVVDLTSFEQ
100
LALPVLRNAD
110
CSSGPGQRVC
120
VIDEIGKMEL
130
FSQLFIQAVR
140
QTLSTPGTII
150
LGTIPVPKGK
160
PLALVEEIRN
170
RKDVKVFNVT
180
KENRNHLLPD
190
IVTCVQSSRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0043273 | CTPase activity |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0017111 | ribonucleoside triphosphate phosphatase activity |
| Molecular Function | GO:0003723 | RNA binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.