Search Results
Overview
| Uniprot ID | Q9BSE5 |
|---|---|
| Protein Name | Guanidino acid hydrolase, mitochondrial |
| Gene Name | AGMAT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | ILQAMAKKHGPVGLL |
| 193 | AHTDTTDKALGEKLY |
| 198 | TDKALGEKLYHGAPF |
| 217 | DEGLLDCKRVVQIGI |
Function
Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency
Protein Sequence
10
MLRLLASGCA
20
RGPGPGVGAR
30
PAAGLFHPGR
40
RQSRQASDAP
50
RNQPPSPEFV
60
ARPVGVCSMM
70
RLPVQTSPEG
80
LDAAFIGVPL
90
DTGTSNRPGA
100
RFGPRRIREE
110
SVMLGTVNPS
120
TGALPFQSLM
130
VADLGDVNVN
140
LYNLQDSCRR
150
IQEAYEKIVA
160
AGCIPLTLGG
170
DHTITYPILQ
180
AMAKKHGPVG
190
LLHVDAHTDT
200
TDKALGEKLY
210
HGAPFRRCVD
220
EGLLDCKRVV
230
QIGIRGSSTT
240
LDPYRYNRSQ
250
GFRVVLAEDC
260
WMKSLVPLMG
270
EVRQQMGGKP
280
IYISFDIDAL
290
DPAYAPGTGT
300
PEIAGLTPSQ
310
ALEIIRGCQG
320
LNVMGCDLVE
330
VSPPYDLSGN
340
TALLAANLLF
350
EMLCALPKVT
TV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008783 | agmatinase activity |
| Molecular Function | GO:0004053 | arginase activity |
| Molecular Function | GO:0047971 | guanidinobutyrase activity |
| Molecular Function | GO:0047972 | guanidinopropionase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0097055 | agmatine biosynthetic process |
| Biological Process | GO:0033389 | putrescine biosynthetic process from arginine, via agmatine |
| Biological Process | GO:0000050 | urea cycle |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.