Search Results

Overview

Uniprot IDQ9BSJ8
Protein NameExtended synaptotagmin-1
Gene NameESYT1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
349 SSKDKYVKGLIEGKS
681 SDPYVKLKLAGRSFR
817 LPLRKGTKHLSPYAT

Function

Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity)

Protein Sequence

10 MERSPGEGPS 20 PSPMDQPSAP 30 SDPTDQPPAA 40 HAKPDPGSGG 50 QPAGPGAAGE 60 ALAVLTSFGR 70 RLLVLIPVYL 80 AGAVGLSVGF 90 VLFGLALYLG 100 WRRVRDEKER 110 SLRAARQLLD 120 DEEQLTAKTL 130 YMSHRELPAW 140 VSFPDVEKAE 150 WLNKIVAQVW 160 PFLGQYMEKL 170 LAETVAPAVR 180 GSNPHLQTFT 190 FTRVELGEKP 200 LRIIGVKVHP 210 GQRKEQILLD 220 LNISYVGDVQ 230 IDVEVKKYFC 240 KAGVKGMQLH 250 GVLRVILEPL 260 IGDLPFVGAV 270 SMFFIRRPTL 280 DINWTGMTNL 290 LDIPGLSSLS 300 DTMIMDSIAA 310 FLVLPNRLLV 320 PLVPDLQDVA 330 QLRSPLPRGI 340 IRIHLLAARG 350 LSSKDKYVKG 360 LIEGKSDPYA 370 LVRLGTQTFC 380 SRVIDEELNP 390 QWGETYEVMV 400 HEVPGQEIEV 410 EVFDKDPDKD 420 DFLGRMKLDV 430 GKVLQASVLD 440 DWFPLQGGQG 450 QVHLRLEWLS 460 LLSDAEKLEQ 470 VLQWNWGVSS 480 RPDPPSAAIL 490 VVYLDRAQDL 500 PLKKGNKEPN 510 PMVQLSIQDV 520 TQESKAVYST 530 NCPVWEEAFR 540 FFLQDPQSQE 550 LDVQVKDDSR 560 ALTLGALTLP 570 LARLLTAPEL 580 ILDQWFQLSS 590 SGPNSRLYMK 600 LVMRILYLDS 610 SEICFPTVPG 620 CPGAWDVDSE 630 NPQRGSSVDA 640 PPRPCHTTPD 650 SQFGTEHVLR 660 IHVLEAQDLI 670 AKDRFLGGLV 680 KGKSDPYVKL 690 KLAGRSFRSH 700 VVREDLNPRW 710 NEVFEVIVTS 720 VPGQELEVEV 730 FDKDLDKDDF 740 LGRCKVRLTT 750 VLNSGFLDEW 760 LTLEDVPSGR 770 LHLRLERLTP 780 RPTAAELEEV 790 LQVNSLIQTQ 800 KSAELAAALL 810 SIYMERAEDL 820 PLRKGTKHLS 830 PYATLTVGDS 840 SHKTKTISQT 850 SAPVWDESAS 860 FLIRKPHTES 870 LELQVRGEGT 880 GVLGSLSLPL 890 SELLVADQLC 900 LDRWFTLSSG 910 QGQVLLRAQL 920 GILVSQHSGV 930 EAHSHSYSHS 940 SSSLSEEPEL 950 SGGPPHITSS 960 APELRQRLTH 970 VDSPLEAPAG 980 PLGQVKLTLW 990 YYSEERKLVS 1000 IVHGCRSLRQ 1010 NGRDPPDPYV 1020 SLLLLPDKNR 1030 GTKRRTSQKK 1040 RTLSPEFNER 1050 FEWELPLDEA 1060 QRRKLDVSVK 1070 SNSSFMSRER 1080 ELLGKVQLDL 1090 AETDLSQGVA 1100 RWYDLMDNKD KGSS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0031210 phosphatidylcholine binding
Molecular Function GO:0008429 phosphatidylethanolamine binding
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0120014 phospholipid transfer activity
Biological Process GO:0061817 endoplasmic reticulum-plasma membrane tethering
Biological Process GO:0120009 intermembrane lipid transfer

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.