Overview
| Uniprot ID | Q9BSM1 |
|---|
| Protein Name | Polycomb group RING finger protein 1 |
|---|
| Gene Name | PCGF1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 184 |
SSGKDKNKSVLQNKY |
| 24 |
NQLQSVYKMDPLRNE |
Function
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479)
Protein Sequence
10
MASPQGGQIA
20
IAMRLRNQLQ
30
SVYKMDPLRN
40
EEEVRVKIKD
50
LNEHIVCCLC
60
AGYFVDATTI
70
TECLHTFCKS
80
CIVKYLQTSK
90
YCPMCNIKIH
100
ETQPLLNLKL
110
DRVMQDIVYK
120
LVPGLQDSEE
130
KRIREFYQSR
140
GLDRVTQPTG
150
EEPALSNLGL
160
PFSSFDHSKA
170
HYYRYDEQLN
180
LCLERLSSGK
190
DKNKSVLQNK
200
YVRCSVRAEV
210
RHLRRVLCHR
220
LMLNPQHVQL
230
LFDNEVLPDH
240
MTMKQIWLSR
250
WFGKPSPLLL
QYSVKEKRR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0031519 |
PcG protein complex |
| Cellular Component |
GO:0035102 |
PRC1 complex |
| Molecular Function |
GO:1990841 |
promoter-specific chromatin binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.