Search Results
Overview
| Uniprot ID | Q9BSQ5 |
|---|---|
| Protein Name | Cerebral cavernous malformations 2 protein |
| Gene Name | CCM2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 23 | PFKRVFLKGEKSRDK |
Function
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity)
Protein Sequence
10
MEEEGKKGKK
20
PGIVSPFKRV
30
FLKGEKSRDK
40
KAHEKVTERR
50
PLHTVVLSLP
60
ERVEPDRLLS
70
DYIEKEVKYL
80
GQLTSIPGYL
90
NPSSRTEILH
100
FIDNAKRAHQ
110
LPGHLTQEHD
120
AVLSLSAYNV
130
KLAWRDGEDI
140
ILRVPIHDIA
150
AVSYVRDDAA
160
HLVVLKTAQD
170
PGISPSQSLC
180
AESSRGLSAG
190
SLSESAVGPV
200
EACCLVILAA
210
ESKVAAEELC
220
CLLGQVFQVV
230
YTESTIDFLD
240
RAIFDGASTP
250
THHLSLHSDD
260
SSTKVDIKET
270
YEVEASTFCF
280
PESVDVGGAS
290
PHSKTISESE
300
LSASATELLQ
310
DYMLTLRTKL
320
SSQEIQQFAA
330
LLHEYRNGAS
340
IHEFCINLRQ
350
LYGDSRKFLL
360
LGLRPFIPEK
370
DSQHFENFLE
380
TIGVKDGRGI
390
ITDSFGRHRR
400
ALSTTSSSTT
410
NGNRATGSSD
420
DRSAPSEGDE
430
WDRMISDISS
440
DIEALGCSMD
QDSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0032991 | protein-containing complex |
| Biological Process | GO:0061154 | endothelial tube morphogenesis |
| Biological Process | GO:0003158 | endothelium development |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0045765 | regulation of angiogenesis |
| Biological Process | GO:0051403 | stress-activated MAPK cascade |
| Biological Process | GO:0001570 | vasculogenesis |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.