Search Results
Overview
| Uniprot ID | Q9BST9 |
|---|---|
| Protein Name | Rhotekin |
| Gene Name | RTKN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | KEAQVLGKTSRRPSD |
| 216 | GPKRLATKLSSSLGR |
Function
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures
Protein Sequence
10
MFSRNHRSRV
20
TVARGSALEM
30
EFKRGRFRLS
40
LFSDLPEDTE
50
LQRKLDHEIR
60
MREGACKLLA
70
ACSQREQALE
80
ATKSLLVCNS
90
RILSYMGELQ
100
RRKEAQVLGK
110
TSRRPSDSGP
120
PAERSPCRGR
130
VCISDLRIPL
140
MWKDTEYFKN
150
KGDLHRWAVF
160
LLLQLGEHIQ
170
DTEMILVDRT
180
LTDISFQSNV
190
LFAEAGPDFE
200
LRLELYGACV
210
EEEGALTGGP
220
KRLATKLSSS
230
LGRSSGRRVR
240
ASLDSAGGSG
250
SSPILLPTPV
260
VGGPRYHLLA
270
HTTLTLAAVQ
280
DGFRTHDLTL
290
ASHEENPAWL
300
PLYGSVCCRL
310
AAQPLCMTQP
320
TASGTLRVQQ
330
AGEMQNWAQV
340
HGVLKGTNLF
350
CYRQPEDADT
360
GEEPLLTIAV
370
NKETRVRAGE
380
LDQALGRPFT
390
LSISNQYGDD
400
EVTHTLQTES
410
REALQSWMEA
420
LWQLFFDMSQ
430
WKQCCDEIMK
440
IETPAPRKPP
450
QALAKQGSLY
460
HEMAIEPLDD
470
IAAVTDILTQ
480
REGARLETPP
490
PWLAMFTDQP
500
ALPNPCSPAS
510
VAPAPDWTHP
520
LPWGRPRTFS
530
LDAVPPDHSP
540
RARSVAPLPP
550
QRSPRTRGLC
560
SKGQPRTWLQ
SPV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005826 | actomyosin contractile ring |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0005095 | GTPase inhibitor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0000915 | actomyosin contractile ring assembly |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0007266 | Rho protein signal transduction |
| Biological Process | GO:0031106 | septin ring organization |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.