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Overview

Uniprot IDQ9BT25
Protein NameHAUS augmin-like complex subunit 8
Gene NameHAUS8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
125 QLAKTISKKPESTSF
45 RYLQYEKKTTQKAPA
74 RKSSLLQKSKADSSG

Function

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex

Protein Sequence

10 MADSSGRGAG 20 KPATGPTNSS 30 SAKKKDKRVQ 40 GGRVIESRYL 50 QYEKKTTQKA 60 PAGDGSQTRG 70 KMSEGGRKSS 80 LLQKSKADSS 90 GVGKGDLQST 100 LLEGHGTAPP 110 DLDLSAINDK 120 SIVKKTPQLA 130 KTISKKPEST 140 SFSAPRKKSP 150 DLSEAMEMME 160 SQTLLLTLLS 170 VKMENNLAEF 180 ERRAEKNLLI 190 MCKEKEKLQK 200 KAHELKRRLL 210 LSQRKRELAD 220 VLDAQIEMLS 230 PFEAVATRFK 240 EQYRTFATAL 250 DTTRHELPVR 260 SIHLEGDGQQ 270 LLDALQHELV 280 TTQRLLGELD 290 VGDSEENVQV 300 LDLLSELKDV 310 TAKKDLELRR 320 SFAQVLELSA 330 EASKEAALAN 340 QEVWEETQGM 350 APPSRWYFNQ 360 DSACRESGGA 370 PKNTPLSEDD 380 NPGASSAPAQ 390 ATFISPSEDF 400 SSSSQAEVPP 410 SLSRSGRDLS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070652 HAUS complex
Cellular Component GO:1990498 mitotic spindle microtubule
Cellular Component GO:0005880 nuclear microtubule
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0051301 cell division
Biological Process GO:0007098 centrosome cycle
Biological Process GO:0010968 regulation of microtubule nucleation
Biological Process GO:0051225 spindle assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.