Search Results

Overview

Uniprot IDQ9BTC0
Protein NameDeath-inducer obliterator 1
Gene NameDIDO1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1239 ATVPQSEKKPSKYPL
182 EPTERPLKGIQSRLR
2096 ERFDVGPKEKPLEEP
372 GIKGRIEKAANPSGK
383 PSGKKKLKIFQPVIE
481 KKETTVKKAVVVPAR
529 PSPSLLYKSTKEDRR
540 EDRRSEEKAAAMAAS
549 AAMAASKKTAPPGSA
570 PRNLVPKKSSFANVA
596 GFKGTIPKRPWLSAT
626 AAATAASKKFPGSAA
627 AATAASKKFPGSAAL
870 AEDEPAPKKQKLSAS
871 EDEPAPKKQKLSASV
873 EPAPKKQKLSASVKK
879 QKLSASVKKEDLKSK

Function

Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development

Protein Sequence

10 MDDKGDPSNE 20 EAPKAIKPTS 30 KEFRKTWGFR 40 RTTIAKREGA 50 GDAEADPLEP 60 PPPQQQLGLS 70 LRRSGRQPKR 80 TERVEQFLTI 90 ARRRGRRSMP 100 VSLEDSGEPT 110 SCPATDAETA 120 SEGSVESASE 130 TRSGPQSAST 140 AVKERPASSE 150 KVKGGDDHDD 160 TSDSDSDGLT 170 LKELQNRLRR 180 KREQEPTERP 190 LKGIQSRLRK 200 KRREEGPAET 210 VGSEASDTVE 220 GVLPSKQEPE 230 NDQGVVSQAG 240 KDDRESKLEG 250 KAAQDIKDEE 260 PGDLGRPKPE 270 CEGYDPNALY 280 CICRQPHNNR 290 FMICCDRCEE 300 WFHGDCVGIS 310 EARGRLLERN 320 GEDYICPNCT 330 ILQVQDETHS 340 ETADQQEAKW 350 RPGDADGTDC 360 TSIGTIEQKS 370 SEDQGIKGRI 380 EKAANPSGKK 390 KLKIFQPVIE 400 APGASKCIGP 410 GCCHVAQPDS 420 VYCSNDCILK 430 HAAATMKFLS 440 SGKEQKPKPK 450 EKMKMKPEKP 460 SLPKCGAQAG 470 IKISSVHKRP 480 APEKKETTVK 490 KAVVVPARSE 500 ALGKEAACES 510 STPSWASDHN 520 YNAVKPEKTA 530 APSPSLLYKS 540 TKEDRRSEEK 550 AAAMAASKKT 560 APPGSAVGKQ 570 PAPRNLVPKK 580 SSFANVAAAT 590 PAIKKPPSGF 600 KGTIPKRPWL 610 SATPSSGASA 620 ARQAGPAPAA 630 ATAASKKFPG 640 SAALVGAVRK 650 PVVPSVPMAS 660 PAPGRLGAMS 670 AAPSQPNSQI 680 RQNIRRSLKE 690 ILWKRVNDSD 700 DLIMTENEVG 710 KIALHIEKEM 720 FNLFQVTDNR 730 YKSKYRSIMF 740 NLKDPKNQGL 750 FHRVLREEIS 760 LAKLVRLKPE 770 ELVSKELSTW 780 KERPARSVME 790 SRTKLHNESK 800 KTAPRQEAIP 810 DLEDSPPVSD 820 SEEQQESARA 830 VPEKSTAPLL 840 DVFSSMLKDT 850 TSQHRAHLFD 860 LNCKICTGQV 870 PSAEDEPAPK 880 KQKLSASVKK 890 EDLKSKHDSS 900 APDPAPDSAD 910 EVMPEAVPEV 920 ASEPGLESAS 930 HPNVDRTYFP 940 GPPGDGHPEP 950 SPLEDLSPCP 960 ASCGSGVVTT 970 VTVSGRDPRT 980 APSSSCTAVA 990 SAASRPDSTH 1000 MVEARQDVPK 1010 PVLTSVMVPK 1020 SILAKPSSSP 1030 DPRYLSVPPS 1040 PNISTSESRS 1050 PPEGDTTLFL 1060 SRLSTIWKGF 1070 INMQSVAKFV 1080 TKAYPVSGCF 1090 DYLSEDLPDT 1100 IHIGGRIAPK 1110 TVWDYVGKLK 1120 SSVSKELCLI 1130 RFHPATEEEE 1140 VAYISLYSYF 1150 SSRGRFGVVA 1160 NNNRHVKDLY 1170 LIPLSAQDPV 1180 PSKLLPFEGP 1190 GLESPRPNII 1200 LGLVICQKIK 1210 RPANSGELDK 1220 MDEKRTRLQP 1230 EEADVPAYPK 1240 VATVPQSEKK 1250 PSKYPLCSAD 1260 AAVSTTPPGS 1270 PPPPPPLPEP 1280 PVLKVLSSLK 1290 PAAPSPATAA 1300 TTAAAASTAA 1310 SSTASSASKT 1320 ASPLEHILQT 1330 LFGKKKSFDP 1340 SAREPPGSTA 1350 GLPQEPKTTA 1360 EDGVPAPPLL 1370 DPIVQQFGQF 1380 SKDKALEEEE 1390 DDRPYDPEEE 1400 YDPERAFDTQ 1410 LVERGRRHEV 1420 ERAPEAAAAE 1430 REEVAYDPED 1440 ETILEEAKVT 1450 VDDLPNRMCA 1460 DVRRNSVERP 1470 AEPVAGAATP 1480 SLVEQQKMLE 1490 ELNKQIEEQK 1500 RQLEEQEEAL 1510 RQQRAAVGVS 1520 MAHFSVSDAL 1530 MSPPPKSSLP 1540 KAELFQQEQQ 1550 SADKPASLPP 1560 ASQASNHRDP 1570 RQARRLATET 1580 GEGEGEPLSR 1590 LSARGAQGAL 1600 PERDASRGGL 1610 VGQAPMPVPE 1620 EKEPASSPWA 1630 SGEKPPAGSE 1640 QDGWKAEPGE 1650 GTRPATVGDS 1660 SARPARRVLL 1670 PTPPCGALQP 1680 GFPLQHDGER 1690 DPFTCPGFAS 1700 QDKALGSAQY 1710 EDPRNLHSAG 1720 RSSSPAGETE 1730 GDREPQARPG 1740 EGTAPLPPPG 1750 QKVGGSQPPF 1760 QGQREPGPHA 1770 LGMSGLHGPN 1780 FPGPRGPAPP 1790 FPEENIASND 1800 GPRGPPPARF 1810 GAQKGPIPSL 1820 FSGQHGPPPY 1830 GDSRGPSPSY 1840 LGGPRGVAPS 1850 QFEERKDPHG 1860 EKREFQDAPY 1870 NEVTGAPAQF 1880 EGTEQAPFLG 1890 SRGGAPFQFG 1900 GQRRPLLSQL 1910 KGPRGGPPPS 1920 QFGGQRGPPP 1930 GHFVGPRGPH 1940 PSQFETARGP 1950 HPNQFEGPRG 1960 QAPNFMPGPR 1970 GIQPQQFEDQ 1980 RVHSPPRFTN 1990 QRAPAPLQFG 2000 GLRGSAPFSE 2010 KNEQTPSRFH 2020 FQGQAPQVMK 2030 PGPRPLLELP 2040 SHPPQHRKDR 2050 WEEAGPPSAL 2060 SSSAPGQGPE 2070 ADGQWASADF 2080 REGKGHEYRN 2090 QTFEGRQRER 2100 FDVGPKEKPL 2110 EEPDAQGRAS 2120 EDRRRERERG 2130 RNWSRERDWD 2140 RPREWDRHRD 2150 KDSSRDWDRN 2160 RERSANRDRE 2170 READRGKEWD 2180 RSRERSRNRE 2190 RERDRRRDRD 2200 RSRSRERDRD 2210 KARDRERGRD 2220 RKDRSKSKES 2230 ARDPKPEASR 2240 ASDAGTASQA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.