Search Results

Overview

Uniprot IDQ9BTC8
Protein NameMetastasis-associated protein MTA3
Gene NameMTA3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
459 VRNTGSPKSAVKTRQ
560 SLQTPTTKRMLTTPN
576 TSLSILGKRNYSHHN

Function

Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082)

Protein Sequence

10 MAANMYRVGD 20 YVYFENSSSN 30 PYLIRRIEEL 40 NKTASGNVEA 50 KVVCFYRRRD 60 ISNTLIMLAD 70 KHAKEIEEES 80 ETTVEADLTD 90 KQKHQLKHRE 100 LFLSRQYESL 110 PATHIRGKCS 120 VALLNETESV 130 LSYLDKEDTF 140 FYSLVYDPSL 150 KTLLADKGEI 160 RVGPRYQADI 170 PEMLLEGESD 180 EREQSKLEVK 190 VWDPNSPLTD 200 RQIDQFLVVA 210 RAVGTFARAL 220 DCSSSVRQPS 230 LHMSAAAASR 240 DITLFHAMDT 250 LYRHSYDLSS 260 AISVLVPLGG 270 PVLCRDEMEE 280 WSASEASLFE 290 EALEKYGKDF 300 NDIRQDFLPW 310 KSLTSIIEYY 320 YMWKTTDRYV 330 QQKRLKAAEA 340 ESKLKQVYIP 350 TYSKPNPNQI 360 STSNGKPGAV 370 NGAVGTTFQP 380 QNPLLGRACE 390 SCYATQSHQW 400 YSWGPPNMQC 410 RLCAICWLYW 420 KKYGGLKMPT 430 QSEEEKLSPS 440 PTTEDPRVRS 450 HVSRQAMQGM 460 PVRNTGSPKS 470 AVKTRQAFFL 480 HTTYFTKFAR 490 QVCKNTLRLR 500 QAARRPFVAI 510 NYAAIRAEYA 520 DRHAELSGSP 530 LKSKSTRKPL 540 ACIIGYLEIH 550 PAKKPNVIRS 560 TPSLQTPTTK 570 RMLTTPNHTS 580 LSILGKRNYS 590 HHNGLDELTC CVSD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016581 NuRD complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0042659 regulation of cell fate specification
Biological Process GO:2000736 regulation of stem cell differentiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.