Search Results
Overview
| Uniprot ID | Q9BTE3 |
|---|---|
| Protein Name | Mini-chromosome maintenance complex-binding protein |
| Gene Name | MCMBP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 180 | DMDLQPNKQKDQHAG |
| 182 | DLQPNKQKDQHAGAR |
Function
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion
Protein Sequence
10
MPCGEDWLSH
20
PLGIVQGFFA
30
QNGVNPDWEK
40
KVIEYFKEKL
50
KENNAPKWVP
60
SLNEVPLHYL
70
KPNSFVKFRC
80
MIQDMFDPEF
90
YMGVYETVNQ
100
NTKAHVLHFG
110
KYRDVAECGP
120
QQELDLNSPR
130
NTTLERQTFY
140
CVPVPGESTW
150
VKEAYVNANQ
160
ARVSPSTSYT
170
PSRHKRSYED
180
DDDMDLQPNK
190
QKDQHAGARQ
200
AGSVGGLQWC
210
GEPKRLETEA
220
STGQQLNSLN
230
LSSPFDLNFP
240
LPGEKGPACL
250
VKVYEDWDCF
260
KVNDILELYG
270
ILSVDPVLSI
280
LNNDERDASA
290
LLDPMECTDT
300
AEEQRVHSPP
310
ASLVPRIHVI
320
LAQKLQHINP
330
LLPACLNKEE
340
SKTCKFVSSF
350
MSELSPVRAE
360
LLGFLTHALL
370
GDSLAAEYLI
380
LHLISTVYTR
390
RDVLPLGKFT
400
VNLSGCPRNS
410
TFTEHLYRII
420
QHLVPASFRL
430
QMTIENMNHL
440
KFIPHKDYTA
450
NRLVSGLLQL
460
PSNTSLVIDE
470
TLLEQGQLDT
480
PGVHNVTALS
490
NLITWQKVDY
500
DFSYHQMEFP
510
CNINVFITSE
520
GRSLLPADCQ
530
IHLQPQLIPP
540
NMEEYMNSLL
550
SAVLPSVLNK
560
FRIYLTLLRF
570
LEYSISDEIT
580
KAVEDDFVEM
590
RKNDPQSITA
600
DDLHQLLVVA
610
RCLSLSAGQT
620
TLSRERWLRA
630
KQLESLRRTR
640
LQQQKCVNGN
EL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0006261 | DNA-templated DNA replication |
| Biological Process | GO:0007062 | sister chromatid cohesion |
Reference
PMID: N/A