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Overview

Uniprot ID	Q9BTK6
Protein Name	PAXIP1-associated glutamate-rich protein 1
Gene Name	PAGR1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
203	KREARLDKVLSDMKR
213	SDMKRHKKLEEQILR

Function

Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582)

Protein Sequence

10 MSLARGHGDT 20 AASTAAPLSE 30 EGEVTSGLQA 40 LAVEDTGGPS 50 ASAGKAEDEG 60 EGGREETERE 70 GSGGEEAQGE 80 VPSAGGEEPA 90 EEDSEDWCVP 100 CSDEEVELPA 110 DGQPWMPPPS 120 EIQRLYELLA 130 AHGTLELQAE 140 ILPRRPPTPE 150 AQSEEERSDE 160 EPEAKEEEEE 170 KPHMPTEFDF 180 DDEPVTPKDS 190 LIDRRRTPGS 200 SARSQKREAR 210 LDKVLSDMKR 220 HKKLEEQILR 230 TGRDLFSLDS 240 EDPSPASPPL 250 RSSGSSLFPR QRKY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0035097	histone methyltransferase complex
Cellular Component	GO:0044666	MLL3/4 complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0030331	nuclear estrogen receptor binding
Biological Process	GO:0006310	DNA recombination
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition
Biological Process	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.