Search Results
Overview
| Uniprot ID | Q9BTM1 |
|---|---|
| Protein Name | Histone H2A.J |
| Gene Name | H2AJ |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | GRGKQGGKVRAKAKS |
| 119 | IQAVLLPKKTESQKT |
| 120 | QAVLLPKKTESQKTK |
| 37 | RVHRLLRKGNYAERV |
| 6 | **MSGRGKQGGKVRA |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MSGRGKQGGK
20
VRAKAKSRSS
30
RAGLQFPVGR
40
VHRLLRKGNY
50
AERVGAGAPV
60
YLAAVLEYLT
70
AEILELAGNA
80
ARDNKKTRII
90
PRHLQLAIRN
100
DEELNKLLGK
110
VTIAQGGVLP
120
NIQAVLLPKK
TESQKTKSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0031507 | heterochromatin formation |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.