Search Results

Overview

Uniprot IDQ9BUJ2
Protein NameHeterogeneous nuclear ribonucleoprotein U-like protein 1
Gene NameHNRNPUL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
146 PEMKTEMKQGAPTSF
172 RQQFQSRKRPYEENR
440 GKTTWAIKHAASNPS
449 AASNPSKKYNILGTN
527 PFEGFQRKAIVICPT
607 KAGPPPEKRFDNRGG

Function

Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro

Protein Sequence

10 MDVRRLKVNE 20 LREELQRRGL 30 DTRGLKAELA 40 ERLQAALEAE 50 EPDDERELDA 60 DDEPGRPGHI 70 NEEVETEGGS 80 ELEGTAQPPP 90 PGLQPHAEPG 100 GYSGPDGHYA 110 MDNITRQNQF 120 YDTQVIKQEN 130 ESGYERRPLE 140 MEQQQAYRPE 150 MKTEMKQGAP 160 TSFLPPEASQ 170 LKPDRQQFQS 180 RKRPYEENRG 190 RGYFEHREDR 200 RGRSPQPPAE 210 EDEDDFDDTL 220 VAIDTYNCDL 230 HFKVARDRSS 240 GYPLTIEGFA 250 YLWSGARASY 260 GVRRGRVCFE 270 MKINEEISVK 280 HLPSTEPDPH 290 VVRIGWSLDS 300 CSTQLGEEPF 310 SYGYGGTGKK 320 STNSRFENYG 330 DKFAENDVIG 340 CFADFECGND 350 VELSFTKNGK 360 WMGIAFRIQK 370 EALGGQALYP 380 HVLVKNCAVE 390 FNFGQRAEPY 400 CSVLPGFTFI 410 QHLPLSERIR 420 GTVGPKSKAE 430 CEILMMVGLP 440 AAGKTTWAIK 450 HAASNPSKKY 460 NILGTNAIMD 470 KMRVMGLRRQ 480 RNYAGRWDVL 490 IQQATQCLNR 500 LIQIAARKKR 510 NYILDQTNVY 520 GSAQRRKMRP 530 FEGFQRKAIV 540 ICPTDEDLKD 550 RTIKRTDEEG 560 KDVPDHAVLE 570 MKANFTLPDV 580 GDFLDEVLFI 590 ELQREEADKL 600 VRQYNEEGRK 610 AGPPPEKRFD 620 NRGGGGFRGR 630 GGGGGFQRYE 640 NRGPPGGNRG 650 GFQNRGGGSG 660 GGGNYRGGFN 670 RSGGGGYSQN 680 RWGNNNRDNN 690 NSNNRGSYNR 700 APQQQPPPQQ 710 PPPPQPPPQQ 720 PPPPPSYSPA 730 RNPPGASTYN 740 KNSNIPGSSA 750 NTSTPTVSSY 760 SPPQPSYSQP 770 PYNQGGYSQG 780 YTAPPPPPPP 790 PPAYNYGSYG 800 GYNPAPYTPP 810 PPPTAQTYPQ 820 PSYNQYQQYA 830 QQWNQYYQNQ 840 GQWPPYYGNY 850 DYGSYSGNTQ GGTSTQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0045202 synapse
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000380 alternative mRNA splicing, via spliceosome
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0009615 response to virus
Biological Process GO:0006396 RNA processing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.