Search Results

Overview

Uniprot IDQ9BUL5
Protein NamePHD finger protein 23
Gene NamePHF23
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 ATLLEKMKLKDSLFD
187 KKDRKNRKLGPGAGA
372 LSCAKIKKTNVPDFF
92 RTIQTFVKKAKSSKR
93 TIQTFVKKAKSSKRR

Function

Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria

Protein Sequence

10 MLEAMAEPSP 20 EDPPPTLKPE 30 TQPPEKRRRT 40 IEDFNKFCSF 50 VLAYAGYIPP 60 SKEESDWPAS 70 GSSSPLRGES 80 AADSDGWDSA 90 PSDLRTIQTF 100 VKKAKSSKRR 110 AAQAGPTQPG 120 PPRSTFSRLQ 130 APDSATLLEK 140 MKLKDSLFDL 150 DGPKVASPLS 160 PTSLTHTSRP 170 PAALTPVPLS 180 QGDLSHPPRK 190 KDRKNRKLGP 200 GAGAGFGVLR 210 RPRPTPGDGE 220 KRSRIKKSKK 230 RKLKKAERGD 240 RLPPPGPPQA 250 PPSDTDSEEE 260 EEEEEEEEEE 270 EMATVVGGEA 280 PVPVLPTPPE 290 APRPPATVHP 300 EGVPPADSES 310 KEVGSTETSQ 320 DGDASSSEGE 330 MRVMDEDIMV 340 ESGDDSWDLI 350 TCYCRKPFAG 360 RPMIECSLCG 370 TWIHLSCAKI 380 KKTNVPDFFY 390 CQKCKELRPE 400 ARRLGGPPKS GEP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006914 autophagy
Biological Process GO:1902902 negative regulation of autophagosome assembly
Biological Process GO:1901097 negative regulation of autophagosome maturation
Biological Process GO:0031398 positive regulation of protein ubiquitination

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.