Search Results
Overview
| Uniprot ID | Q9BUP0 |
|---|---|
| Protein Name | EF-hand domain-containing protein D1 |
| Gene Name | EFHD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 204 | QALSSASKFEAELKA |
Function
Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899). May play a role in neuronal differentiation (By similarity)
Protein Sequence
10
MASEELACKL
20
ERRLRREEAE
30
ESGPQLAPLG
40
APAPEPKPEP
50
EPPARAPTAS
60
ADAELSAQLS
70
RRLDINEGAA
80
RPRRCRVFNP
90
YTEFPEFSRR
100
LIKDLESMFK
110
LYDAGRDGFI
120
DLMELKLMME
130
KLGAPQTHLG
140
LKSMIKEVDE
150
DFDGKLSFRE
160
FLLIFHKAAA
170
GELQEDSGLM
180
ALAKLSEIDV
190
ALEGVKGAKN
200
FFEAKVQALS
210
SASKFEAELK
220
AEQDERKREE
230
EERRLRQAAF
QKLKANFNT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0061891 | calcium ion sensor activity |
| Biological Process | GO:1900069 | regulation of cellular hyperosmotic salinity response |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.