Search Results
Overview
| Uniprot ID | Q9BUP3 |
|---|---|
| Protein Name | Protein HTATIP2 |
| Gene Name | HTATIP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 54 | VTLIGRRKLTFDEEA |
Function
Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672)
Protein Sequence
10
MAETEALSKL
20
REDFRMQNKS
30
VFILGASGET
40
GRVLLKEILE
50
QGLFSKVTLI
60
GRRKLTFDEE
70
AYKNVNQEVV
80
DFEKLDDYAS
90
AFQGHDVGFC
100
CLGTTRGKAG
110
AEGFVRVDRD
120
YVLKSAELAK
130
AGGCKHFNLL
140
SSKGADKSSN
150
FLYLQVKGEV
160
EAKVEELKFD
170
RYSVFRPGVL
180
LCDRQESRPG
190
EWLVRKFFGS
200
LPDSWASGHS
210
VPVVTVVRAM
220
LNNVVRPRDK
230
QMELLENKAI
240
HDLGKAHGSL
KP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0043068 | positive regulation of programmed cell death |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0046777 | protein autophosphorylation |
| Biological Process | GO:0006417 | regulation of translation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.