Search Results
Overview
| Uniprot ID | Q9BV38 |
|---|---|
| Protein Name | WD repeat-containing protein 18 |
| Gene Name | WDR18 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 432 | RFITRPAK******* |
Function
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). May play a role during development (By similarity)
Protein Sequence
10
MAAPMEVAVC
20
TDSAAPMWSC
30
IVWELHSGAN
40
LLTYRGGQAG
50
PRGLALLNGE
60
YLLAAQLGKN
70
YISAWELQRK
80
DQLQQKIMCP
90
GPVTCLTASP
100
NGLYVLAGVA
110
ESIHLWEVST
120
GNLLVILSRH
130
YQDVSCLQFT
140
GDSSHFISGG
150
KDCLVLVWSL
160
CSVLQADPSR
170
IPAPRHVWSH
180
HALPITDLHC
190
GFGGPLARVA
200
TSSLDQTVKL
210
WEVSSGELLL
220
SVLFDVSIMA
230
VTMDLAEHHM
240
FCGGSEGSIF
250
QVDLFTWPGQ
260
RERSFHPEQD
270
AGKVFKGHRN
280
QVTCLSVSTD
290
GSVLLSGSHD
300
ETVRLWDVQS
310
KQCIRTVALK
320
GPVTNAAILL
330
APVSMLSSDF
340
RPSLPLPHFN
350
KHLLGAEHGD
360
EPRHGGLTLR
370
LGLHQQGSEP
380
SYLDRTEQLQ
390
AVLCSTMEKS
400
VLGGQDQLRV
410
RVTELEDEVR
420
NLRKINRDLF
430
DFSTRFITRP
AK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0120293 | dynein axonemal particle |
| Cellular Component | GO:0005656 | nuclear pre-replicative complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0120330 | rixosome complex |
| Biological Process | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0006261 | DNA-templated DNA replication |
| Biological Process | GO:0006364 | rRNA processing |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.