Search Results

Overview

Uniprot IDQ9BV73
Protein NameCentrosome-associated protein CEP250
Gene NameCEP250
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1728 RGSLEHMKLILRDKE

Function

Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958)

Protein Sequence

10 METRSPGLNN 20 MKPQSLQLVL 30 EEQVLALQQQ 40 MAENQAASWR 50 KLKNSQEAQQ 60 RQATLVRKLQ 70 AKVLQYRSWC 80 QELEKRLEAT 90 GGPIPQRWEN 100 VEEPNLDELL 110 VRLEEEQQRC 120 ESLAEVNTQL 130 RLHMEKADVV 140 NKALREDVEK 150 LTVDWSRARD 160 ELMRKESQWQ 170 MEQEFFKGYL 180 KGEHGRLLSL 190 WREVVTFRRH 200 FLEMKSATDR 210 DLMELKAEHV 220 RLSGSLLTCC 230 LRLTVGAQSR 240 EPNGSGRMDG 250 REPAQLLLLL 260 AKTQELEKEA 270 HERSQELIQL 280 KSQGDLEKAE 290 LQDRVTELSA 300 LLTQSQKQNE 310 DYEKMIKALR 320 ETVEILETNH 330 TELMEHEASL 340 SRNAQEEKLS 350 LQQVIKDITQ 360 VMVEEGDNIA 370 QGSGHENSLE 380 LDSSIFSQFD 390 YQDADKALTL 400 VRSVLTRRRQ 410 AVQDLRQQLA 420 GCQEAVNLLQ 430 QQHDQWEEEG 440 KALRQRLQKL 450 TGERDTLAGQ 460 TVDLQGEVDS 470 LSKERELLQK 480 AREELRQQLE 490 VLEQEAWRLR 500 RVNVELQLQG 510 DSAQGQKEEQ 520 QEELHLAVRE 530 RERLQEMLMG 540 LEAKQSESLS 550 ELITLREALE 560 SSHLEGELLR 570 QEQTEVTAAL 580 ARAEQSIAEL 590 SSSENTLKTE 600 VADLRAAAVK 610 LSALNEALAL 620 DKVGLNQQLL 630 QLEEENQSVC 640 SRMEAAEQAR 650 NALQVDLAEA 660 EKRREALWEK 670 NTHLEAQLQK 680 AEEAGAELQA 690 DLRDIQEEKE 700 EIQKKLSESR 710 HQQEAATTQL 720 EQLHQEAKRQ 730 EEVLARAVQE 740 KEALVREKAA 750 LEVRLQAVER 760 DRQDLAEQLQ 770 GLSSAKELLE 780 SSLFEAQQQN 790 SVIEVTKGQL 800 EVQIQTVTQA 810 KEVIQGEVRC 820 LKLELDTERS 830 QAEQERDAAA 840 RQLAQAEQEG 850 KTALEQQKAA 860 HEKEVNQLRE 870 KWEKERSWHQ 880 QELAKALESL 890 EREKMELEMR 900 LKEQQTEMEA 910 IQAQREEERT 920 QAESALCQMQ 930 LETEKERVSL 940 LETLLQTQKE 950 LADASQQLER 960 LRQDMKVQKL 970 KEQETTGILQ 980 TQLQEAQREL 990 KEAARQHRDD 1000 LAALQEESSS 1010 LLQDKMDLQK 1020 QVEDLKSQLV 1030 AQDDSQRLVE 1040 QEVQEKLRET 1050 QEYNRIQKEL 1060 EREKASLTLS 1070 LMEKEQRLLV 1080 LQEADSIRQQ 1090 ELSALRQDMQ 1100 EAQGEQKELS 1110 AQMELLRQEV 1120 KEKEADFLAQ 1130 EAQLLEELEA 1140 SHITEQQLRA 1150 SLWAQEAKAA 1160 QLQLRLRSTE 1170 SQLEALAAEQ 1180 QPGNQAQAQA 1190 QLASLYSALQ 1200 QALGSVCESR 1210 PELSGGGDSA 1220 PSVWGLEPDQ 1230 NGARSLFKRG 1240 PLLTALSAEA 1250 VASALHKLHQ 1260 DLWKTQQTRD 1270 VLRDQVQKLE 1280 ERLTDTEAEK 1290 SQVHTELQDL 1300 QRQLSQNQEE 1310 KSKWEGKQNS 1320 LESELMELHE 1330 TMASLQSRLR 1340 RAELQRMEAQ 1350 GERELLQAAK 1360 ENLTAQVEHL 1370 QAAVVEARAQ 1380 ASAAGILEED 1390 LRTARSALKL 1400 KNEEVESERE 1410 RAQALQEQGE 1420 LKVAQGKALQ 1430 ENLALLTQTL 1440 AEREEEVETL 1450 RGQIQELEKQ 1460 REMQKAALEL 1470 LSLDLKKRNQ 1480 EVDLQQEQIQ 1490 ELEKCRSVLE 1500 HLPMAVQERE 1510 QKLTVQREQI 1520 RELEKDRETQ 1530 RNVLEHQLLE 1540 LEKKDQMIES 1550 QRGQVQDLKK 1560 QLVTLECLAL 1570 ELEENHHKME 1580 CQQKLIKELE 1590 GQRETQRVAL 1600 THLTLDLEER 1610 SQELQAQSSQ 1620 IHDLESHSTV 1630 LARELQERDQ 1640 EVKSQREQIE 1650 ELQRQKEHLT 1660 QDLERRDQEL 1670 MLQKERIQVL 1680 EDQRTRQTKI 1690 LEEDLEQIKL 1700 SLRERGRELT 1710 TQRQLMQERA 1720 EEGKGPSKAQ 1730 RGSLEHMKLI 1740 LRDKEKEVEC 1750 QQEHIHELQE 1760 LKDQLEQQLQ 1770 GLHRKVGETS 1780 LLLSQREQEI 1790 VVLQQQLQEA 1800 REQGELKEQS 1810 LQSQLDEAQR 1820 ALAQRDQELE 1830 ALQQEQQQAQ 1840 GQEERVKEKA 1850 DALQGALEQA 1860 HMTLKERHGE 1870 LQDHKEQARR 1880 LEEELAVEGR 1890 RVQALEEVLG 1900 DLRAESREQE 1910 KALLALQQQC 1920 AEQAQEHEVE 1930 TRALQDSWLQ 1940 AQAVLKERDQ 1950 ELEALRAESQ 1960 SSRHQEEAAR 1970 ARAEALQEAL 1980 GKAHAALQGK 1990 EQHLLEQAEL 2000 SRSLEASTAT 2010 LQASLDACQA 2020 HSRQLEEALR 2030 IQEGEIQDQD 2040 LRYQEDVQQL 2050 QQALAQRDEE 2060 LRHQQEREQL 2070 LEKSLAQRVQ 2080 ENMIQEKQNL 2090 GQEREEEEIR 2100 GLHQSVRELQ 2110 LTLAQKEQEI 2120 LELRETQQRN 2130 NLEALPHSHK 2140 TSPMEEQSLK 2150 LDSLEPRLQR 2160 ELERLQAALR 2170 QTEAREIEWR 2180 EKAQDLALSL 2190 AQTKASVSSL 2200 QEVAMFLQAS 2210 VLERDSEQQR 2220 LQDELELTRR 2230 ALEKERLHSP 2240 GATSTAELGS 2250 RGEQGVQLGE 2260 VSGVEAEPSP 2270 DGMEKQSWRQ 2280 RLEHLQQAVA 2290 RLEIDRSRLQ 2300 RHNVQLRSTL 2310 EQVERERRKL 2320 KREAMRAAQA 2330 GSLEISKATA 2340 SSPTQQDGRG 2350 QKNSDAKCVA 2360 ELQKEVVLLQ 2370 AQLTLERKQK 2380 QDYITRSAQT 2390 SRELAGLHHS 2400 LSHSLLAVAQ 2410 APEATVLEAE 2420 TRRLDESLTQ 2430 SLTSPGPVLL 2440 HPSPSTTQAA SR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005814 centriole
Cellular Component GO:0005813 centrosome
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0001750 photoreceptor outer segment
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0031616 spindle pole centrosome
Molecular Function GO:0019904 protein domain specific binding
Biological Process GO:0010457 centriole-centriole cohesion
Biological Process GO:0060271 cilium assembly
Biological Process GO:0050908 detection of light stimulus involved in visual perception
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:1905515 non-motile cilium assembly
Biological Process GO:1904781 positive regulation of protein localization to centrosome
Biological Process GO:0071539 protein localization to centrosome
Biological Process GO:0030997 regulation of centriole-centriole cohesion

Reference

[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.