Search Results

Overview

Uniprot IDQ9BV79
Protein NameEnoyl-[acyl-carrier-protein] reductase, mitochondrial
Gene NameMECR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
223 RDRPDIQKLSDRLKS
252 PEMKNFFKDMPQPRL
267 ALNCVGGKSSTELLR
56 GHHGDPAKVVELKNL
61 PAKVVELKNLELAAV

Function

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (PubMed:12654921, PubMed:18479707, PubMed:27817865). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (PubMed:37653044). Required for proper morphology and bioenergetic functions of mitochondria (PubMed:37653044). Required for maintenance of neurons (By similarity)

Protein Sequence

10 MWVCSTLWRV 20 RTPARQWRGL 30 LPASGCHGPA 40 ASSYSASAEP 50 ARVRALVYGH 60 HGDPAKVVEL 70 KNLELAAVRG 80 SDVRVKMLAA 90 PINPSDINMI 100 QGNYGFLPEL 110 PAVGGNEGVA 120 QVVAVGSNVT 130 GLKPGDWVIP 140 ANAGLGTWRT 150 EAVFSEEALI 160 QVPSDIPLQS 170 AATLGVNPCT 180 AYRMLMDFEQ 190 LQPGDSVIQN 200 ASNSGVGQAV 210 IQIAAALGLR 220 TINVVRDRPD 230 IQKLSDRLKS 240 LGAEHVITEE 250 ELRRPEMKNF 260 FKDMPQPRLA 270 LNCVGGKSST 280 ELLRQLARGG 290 TMVTYGGMAK 300 QPVVASVSLL 310 IFKDLKLRGF 320 WLSQWKKDHS 330 PDQFKELILT 340 LCDLIRRGQL 350 TAPACSQVPL 360 QDYQSALEAS 370 MKPFISSKQI LTM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Biological Process GO:0046513 ceramide biosynthetic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0006879 intracellular iron ion homeostasis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.