Search Results
Overview
| Uniprot ID | Q9BVA0 |
|---|---|
| Protein Name | Katanin p80 WD40 repeat-containing subunit B1 |
| Gene Name | KATNB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 466 | RNEPIGLKASDFLPA |
Function
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth
Protein Sequence
10
MATPVVTKTA
20
WKLQEIVAHA
30
SNVSSLVLGK
40
ASGRLLATGG
50
DDCRVNLWSI
60
NKPNCIMSLT
70
GHTSPVESVR
80
LNTPEELIVA
90
GSQSGSIRVW
100
DLEAAKILRT
110
LMGHKANICS
120
LDFHPYGEFV
130
ASGSQDTNIK
140
LWDIRRKGCV
150
FRYRGHSQAV
160
RCLRFSPDGK
170
WLASAADDHT
180
VKLWDLTAGK
190
MMSEFPGHTG
200
PVNVVEFHPN
210
EYLLASGSSD
220
RTIRFWDLEK
230
FQVVSCIEGE
240
PGPVRSVLFN
250
PDGCCLYSGC
260
QDSLRVYGWE
270
PERCFDVVLV
280
NWGKVADLAI
290
CNDQLIGVAF
300
SQSNVSSYVV
310
DLTRVTRTGT
320
VARDPVQDHR
330
PLAQPLPNPS
340
APLRRIYERP
350
STTCSKPQRV
360
KQNSESERRS
370
PSSEDDRDER
380
ESRAEIQNAE
390
DYNEIFQPKN
400
SISRTPPRRS
410
EPFPAPPEDD
420
AATAKEAAKP
430
SPAMDVQFPV
440
PNLEVLPRPP
450
VVASTPAPKA
460
EPAIIPATRN
470
EPIGLKASDF
480
LPAVKIPQQA
490
ELVDEDAMSQ
500
IRKGHDTMCV
510
VLTSRHKNLD
520
TVRAVWTMGD
530
IKTSVDSAVA
540
INDLSVVVDL
550
LNIVNQKASL
560
WKLDLCTTVL
570
PQIEKLLQSK
580
YESYVQTGCT
590
SLKLILQRFL
600
PLITDMLAAP
610
PSVGVDISRE
620
ERLHKCRLCY
630
KQLKSISGLV
640
KSKSGLSGRH
650
GSTFRELHLL
MASLD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0008352 | katanin complex |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0060590 | ATPase regulator activity |
| Molecular Function | GO:0070840 | dynein complex binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0007019 | microtubule depolymerization |
| Biological Process | GO:0051013 | microtubule severing |
| Biological Process | GO:0007079 | mitotic chromosome movement towards spindle pole |
| Biological Process | GO:0007026 | negative regulation of microtubule depolymerization |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0031117 | positive regulation of microtubule depolymerization |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0006605 | protein targeting |
Reference
PMID: N/A