Search Results
Overview
| Uniprot ID | Q9BVC3 |
|---|---|
| Protein Name | Sister chromatid cohesion protein DCC1 |
| Gene Name | DSCC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 282 | MLLQNAVKFNLAEFQ |
Function
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3
Protein Sequence
10
MKRTRDEVDA
20
TLQIAKLNAA
30
ELLPAVHCLG
40
FGPGASGAAA
50
GDFCLLELEP
60
TLCQQLEDGH
70
SLVIRGDKDE
80
QAVLCSKDKT
90
YDLKIADTSN
100
MLLFIPGCKT
110
PDQLKKEDSH
120
CNIIHTEIFG
130
FSNNYWELRR
140
RRPKLKKLKK
150
LLMENPYEGP
160
DSQKEKDSNS
170
SKYTTEDLLD
180
QIQASEEEIM
190
TQLQVLNACK
200
IGGYWRILEF
210
DYEMKLLNHV
220
TQLVDSESWS
230
FGKVPLNTCL
240
QELGPLEPEE
250
MIEHCLKCYG
260
KKYVDEGEVY
270
FELDADKICR
280
AAARMLLQNA
290
VKFNLAEFQE
300
VWQQSVPEGM
310
VTSLDQLKGL
320
ALVDRHSRPE
330
IIFLLKVDDL
340
PEDNQERFNS
350
LFSLREKWTE
360
EDIAPYIQDL
370
CGEKQTIGAL
380
LTKYSHSSMQ
390
NGVKVYNSRR
PIS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000775 | chromosome, centromeric region |
| Cellular Component | GO:0031390 | Ctf18 RFC-like complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0034088 | maintenance of mitotic sister chromatid cohesion |
| Biological Process | GO:1900264 | positive regulation of DNA-directed DNA polymerase activity |
| Biological Process | GO:0034421 | post-translational protein acetylation |
| Biological Process | GO:0006275 | regulation of DNA replication |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.