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Overview

Uniprot ID	Q9BVC6
Protein Name	Voltage-gated monoatomic cation channel TMEM109
Gene Name	TMEM109
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
215	SGAQLEAKVRGLERQ

Function

Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium (By similarity). Plays a role in the cellular response to DNA damage (PubMed:23542032)

Protein Sequence

10 MAASSISSPW 20 GKHVFKAILM 30 VLVALILLHS 40 ALAQSRRDFA 50 PPGQQKREAP 60 VDVLTQIGRS 70 VRGTLDAWIG 80 PETMHLVSES 90 SSQVLWAISS 100 AISVAFFALS 110 GIAAQLLNAL 120 GLAGDYLAQG 130 LKLSPGQVQT 140 FLLWGAGALV 150 VYWLLSLLLG 160 LVLALLGRIL 170 WGLKLVIFLA 180 GFVALMRSVP 190 DPSTRALLLL 200 ALLILYALLS 210 RLTGSRASGA 220 QLEAKVRGLE 230 RQVEELRWRQ 240 RRAAKGARSV EEE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0034702	monoatomic ion channel complex
Cellular Component	GO:0005640	nuclear outer membrane
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity
Biological Process	GO:0071480	cellular response to gamma radiation
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process	GO:0043069	negative regulation of programmed cell death

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.