Search Results

Overview

Uniprot IDQ9BVI0
Protein NamePHD finger protein 20
Gene NamePHF20
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 DCRFYPAKVTAVNKD

Function

Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage

Protein Sequence

10 MTKHPPNRRG 20 ISFEVGAQLE 30 ARDRLKNWYP 40 AHIEDIDYEE 50 GKVLIHFKRW 60 NHRYDEWFCW 70 DSPYLRPLEK 80 IQLRKEGLHE 90 EDGSSEFQIN 100 EQVLACWSDC 110 RFYPAKVTAV 120 NKDGTYTVKF 130 YDGVVQTVKH 140 IHVKAFSKDQ 150 NIVGNARPKE 160 TDHKSLSSSP 170 DKREKFKEQR 180 KATVNVKKDK 190 EDKPLKTEKR 200 PKQPDKEGKL 210 ICSEKGKVSE 220 KSLPKNEKED 230 KENISENDRE 240 YSGDAQVDKK 250 PENDIVKSPQ 260 ENLREPKRKR 270 GRPPSIAPTA 280 VDSNSQTLQP 290 ITLELRRRKI 300 SKGCEVPLKR 310 PRLDKNSSQE 320 KSKNYSENTD 330 KDLSRRRSSR 340 LSTNGTHEIL 350 DPDLVVSDLV 360 DTDPLQDTLS 370 STKESEEGQL 380 KSALEAGQVS 390 SALTCHSFGD 400 GSGAAGLELN 410 CPSMGENTMK 420 TEPTSPLVEL 430 QEISTVEVTN 440 TFKKTDDFGS 450 SNAPAVDLDH 460 KFRCKVVDCL 470 KFFRKAKLLH 480 YHMKYFHGME 490 KSLEPEESPG 500 KRHVQTRGPS 510 ASDKPSQETL 520 TRKRVSASSP 530 TTKDKEKNKE 540 KKFKEFVRVK 550 PKKKKKKKKK 560 TKPECPCSEE 570 ISDTSQEPSP 580 PKAFAVTRCG 590 SSHKPGVHMS 600 PQLHGPESGH 610 HKGKVKALEE 620 DNLSESSSES 630 FLWSDDEYGQ 640 DVDVTTNPDE 650 ELDGDDRYDF 660 EVVRCICEVQ 670 EENDFMIQCE 680 ECQCWQHGVC 690 MGLLEENVPE 700 KYTCYVCQDP 710 PGQRPGFKYW 720 YDKEWLSRGH 730 MHGLAFLEEN 740 YSHQNAKKIV 750 ATHQLLGDVQ 760 RVIEVLHGLQ 770 LKMSILQSRE 780 HPDLPLWCQP 790 WKQHSGEGRS 800 HFRNIPVTDT 810 RSKEEAPSYR 820 TLNGAVEKPR 830 PLALPLPRSV 840 EESYITSEHC 850 YQKPRAYYPA 860 VEQKLVVETR 870 GSALDDAVNP 880 LHENGDDSLS 890 PRLGWPLDQD 900 RSKGDSDPKP 910 GSPKVKEYVS 920 KKALPEEAPA 930 RKLLDRGGEG 940 LLSSQHQWQF 950 NLLTHVESLQ 960 DEVTHRMDSI 970 EKELDVLESW 980 LDYTGELEPP 990 EPLARLPQLK 1000 HCIKQLLMDL 1010 GKVQQIALCC ST

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000123 histone acetyltransferase complex
Cellular Component GO:0071339 MLL1 complex
Cellular Component GO:0044545 NSL complex
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.