Search Results

Overview

Uniprot ID	Q9BVL2
Protein Name	Nucleoporin p58/p45
Gene Name	NUP58
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
231	SSDKKSDKTGTRPED
312	TLNIDKLKIETAQEL
330	EIALRTQKTPPGLQH
441	TRRAEAKKWQNTPRV

Function

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane

Protein Sequence

10 MSTGFSFGSG 20 TLGSTTVAAG 30 GTSTGGVFSF 40 GTGASSNPSV 50 GLNFGNLGST 60 STPATTSAPS 70 SGFGTGLFGS 80 KPATGFTLGG 90 TNTGIATTIT 100 TGLTLGTPAT 110 TSAATTGFSL 120 GFNKPAASAT 130 PFALPITSTS 140 ASGLTLSSAL 150 TSTPAASTGF 160 TLNNLGGTTA 170 TTTTASTGLS 180 LGGALAGLGG 190 SLFQSTNTGT 200 SGLGQNALGL 210 TLGTTAATST 220 AGNEGLGGID 230 FSSSSDKKSD 240 KTGTRPEDSK 250 ALKDENLPPV 260 ICQDVENLQK 270 FVKEQKQVQE 280 EISRMSSKAM 290 LKVQEDIKAL 300 KQLLSLAANG 310 IQRNTLNIDK 320 LKIETAQELK 330 NAEIALRTQK 340 TPPGLQHEYA 350 APADYFRILV 360 QQFEVQLQQY 370 RQQIEELENH 380 LATQANNSHI 390 TPQDLSMAMQ 400 KIYQTFVALA 410 AQLQSIHENV 420 KVLKEQYLGY 430 RKMFLGDAVD 440 VFETRRAEAK 450 KWQNTPRVTT 460 GPTPFSTMPN 470 AAAVAMAATL 480 TQQQQPATGP 490 QPSLGVSFGT 500 PFGSGIGTGL 510 QSSGLGSSNL 520 GGFGTSSGFG 530 CSTTGASTFG 540 FGTTNKPSGS 550 LSAGFGSSST 560 SGFNFSNPGI 570 TASAGLTFGV 580 SNPASAGFGT 590 GGQLLQLKKP PAGNKRGKR

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0042306	regulation of protein import into nucleus
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005643	nuclear pore
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0008139	nuclear localization sequence binding
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0017056	structural constituent of nuclear pore
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0015031	protein transport

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.