Search Results

Overview

Uniprot ID	Q9BVP2
Protein Name	Guanine nucleotide-binding protein-like 3
Gene Name	GNL3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
114	EKEFGLCKTENKAKS
224	TKRVKAKKNAAPFRS
377	QRRGMHQKGGIPNVE
46	RGHKKPRKDPGVPNS
91	KELEKKRKLETNPDI

Function

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)

Protein Sequence

10 MKRPKLKKAS 20 KRMTCHKRYK 30 IQKKVREHHR 40 KLRKEAKKRG 50 HKKPRKDPGV 60 PNSAPFKEAL 70 LREAELRKQR 80 LEELKQQQKL 90 DRQKELEKKR 100 KLETNPDIKP 110 SNVEPMEKEF 120 GLCKTENKAK 130 SGKQNSKKLY 140 CQELKKVIEA 150 SDVVLEVLDA 160 RDPLGCRCPQ 170 VEEAIVQSGQ 180 KKLVLILNKS 190 DLVPKENLES 200 WLNYLKKELP 210 TVVFRASTKP 220 KDKGKITKRV 230 KAKKNAAPFR 240 SEVCFGKEGL 250 WKLLGGFQET 260 CSKAIRVGVI 270 GFPNVGKSSI 280 INSLKQEQMC 290 NVGVSMGLTR 300 SMQVVPLDKQ 310 ITIIDSPSFI 320 VSPLNSSSAL 330 ALRSPASIEV 340 VKPMEAASAI 350 LSQADARQVV 360 LKYTVPGYRN 370 SLEFFTVLAQ 380 RRGMHQKGGI 390 PNVEGAAKLL 400 WSEWTGASLA 410 YYCHPPTSWT 420 PPPYFNESIV 430 VDMKSGFNLE 440 ELEKNNAQSI 450 RAIKGPHLAN 460 SILFQSSGLT 470 NGIIEEKDIH 480 EELPKRKERK 490 QEEREDDKDS 500 DQETVDEEVD 510 ENSSGMFAAE 520 ETGEALSEET 530 TAGEQSTRSF 540 ILDKIIEEDD AYDFSTDYV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0048027	mRNA 5'-UTR binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:1902895	positive regulation of miRNA transcription
Biological Process	GO:1904816	positive regulation of protein localization to chromosome, telomeric region
Biological Process	GO:0033235	positive regulation of protein sumoylation
Biological Process	GO:0032206	positive regulation of telomere maintenance
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0017145	stem cell division
Biological Process	GO:0019827	stem cell population maintenance

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.