Search Results
Overview
| Uniprot ID | Q9BVS4 |
|---|---|
| Protein Name | Serine/threonine-protein kinase RIO2 |
| Gene Name | RIOK2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 523 | AVRRRLQKGEANIFT |
Function
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710)
Protein Sequence
10
MGKVNVAKLR
20
YMSRDDFRVL
30
TAVEMGMKNH
40
EIVPGSLIAS
50
IASLKHGGCN
60
KVLRELVKHK
70
LIAWERTKTV
80
QGYRLTNAGY
90
DYLALKTLSS
100
RQVVESVGNQ
110
MGVGKESDIY
120
IVANEEGQQF
130
ALKLHRLGRT
140
SFRNLKNKRD
150
YHKHRHNVSW
160
LYLSRLSAMK
170
EFAYMKALYE
180
RKFPVPKPID
190
YNRHAVVMEL
200
INGYPLCQIH
210
HVEDPASVYD
220
EAMELIVKLA
230
NHGLIHGDFN
240
EFNLILDESD
250
HITMIDFPQM
260
VSTSHPNAEW
270
YFDRDVKCIK
280
DFFMKRFSYE
290
SELFPTFKDI
300
RREDTLDVEV
310
SASGYTKEMQ
320
ADDELLHPLG
330
PDDKNIETKE
340
GSEFSFSDGE
350
VAEKAEVYGS
360
ENESERNCLE
370
ESEGCYCRSS
380
GDPEQIKEDS
390
LSEESADARS
400
FEMTEFNQAL
410
EEIKGQVVEN
420
NSVTEFSEEK
430
NRTENYNRQD
440
GQRVQGGVPA
450
GSDEYEDECP
460
HLIALSSLNR
470
EFRPFRDEEN
480
VGAMNQYRTR
490
TLSITSSGSA
500
VSCSTIPPEL
510
VKQKVKRQLT
520
KQQKSAVRRR
530
LQKGEANIFT
540
KQRRENMQNI
550
KSSLEAASFW
GE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030688 | preribosome, small subunit precursor |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0030490 | maturation of SSU-rRNA |
| Biological Process | GO:2000208 | positive regulation of ribosomal small subunit export from nucleus |
| Biological Process | GO:2000234 | positive regulation of rRNA processing |
| Biological Process | GO:0030071 | regulation of mitotic metaphase/anaphase transition |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
Reference
PMID: N/A