Search Results
Overview
| Uniprot ID | Q9BVW5 |
|---|---|
| Protein Name | TIMELESS-interacting protein |
| Gene Name | TIPIN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | KEVQTCLKRIRLDLP |
Function
Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232)
Protein Sequence
10
MLEPQENGVI
20
DLPDYEHVED
30
ETFPPFPPPA
40
SPERQDGEGT
50
EPDEESGNGA
60
PVRVPPKRTV
70
KRNIPKLDAQ
80
RLISERGLPA
90
LRHVFDKAKF
100
KGKGHEAEDL
110
KMLIRHMEHW
120
AHRLFPKLQF
130
EDFIDRVEYL
140
GSKKEVQTCL
150
KRIRLDLPIL
160
HEDFVSNNDE
170
VAENNEHDVT
180
STELDPFLTN
190
LSESEMFASE
200
LSRSLTEEQQ
210
QRIERNKQLA
220
LERRQAKLLS
230
NSQTLGNDML
240
MNTPRAHTVE
250
EVNTDEDQKE
260
ESNGLNEDIL
270
DNPCNDAIAN
280
TLNEEETLLD
290
QSFKNVQQQL
300
DATSRNITEA
R
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0043596 | nuclear replication fork |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031298 | replication fork protection complex |
| Molecular Function | GO:0003677 | DNA binding |
| Biological Process | GO:0044770 | cell cycle phase transition |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0000076 | DNA replication checkpoint signaling |
| Biological Process | GO:0031573 | mitotic intra-S DNA damage checkpoint signaling |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0033262 | regulation of nuclear cell cycle DNA replication |
| Biological Process | GO:0043111 | replication fork arrest |
| Biological Process | GO:0031297 | replication fork processing |
Reference
PMID: N/A