Search Results

Overview

Uniprot ID	Q9BW30
Protein Name	Tubulin polymerization-promoting protein family member 3
Gene Name	TPPP3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
115	PANVGVTKAKTGGAV
117	NVGVTKAKTGGAVDR
165	SGYVSAYKNAGTYDA
173	NAGTYDAKVKK****
24	FAIHGDPKASGQEMN
48	DCKVADGKSVTGTDV
61	DVDIVFSKVKGKSAR

Function

Regulator of microtubule dynamic that has microtubule bundling activity (PubMed:17105200, PubMed:19633818). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (PubMed:30667362)

Protein Sequence

10 MAASTDMAGL 20 EESFRKFAIH 30 GDPKASGQEM 40 NGKNWAKLCK 50 DCKVADGKSV 60 TGTDVDIVFS 70 KVKGKSARVI 80 NYEEFKKALE 90 ELATKRFKGK 100 SKEEAFDAIC 110 QLVAGKEPAN 120 VGVTKAKTGG 130 AVDRLTDTSR 140 YTGSHKERFD 150 ESGKGKGIAG 160 RQDILDDSGY 170 VSAYKNAGTY DAKVKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005874	microtubule
Molecular Function	GO:0015631	tubulin binding
Biological Process	GO:0046697	decidualization
Biological Process	GO:0007566	embryo implantation
Biological Process	GO:0001578	microtubule bundle formation
Biological Process	GO:0046785	microtubule polymerization
Biological Process	GO:0032273	positive regulation of protein polymerization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.