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Overview

Uniprot IDQ9BW60
Protein NameVery long chain fatty acid elongase 1
Gene NameELOVL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
54 PRIMANRKPFQLRGF

Function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs

Protein Sequence

10 MEAVVNLYQE 20 VMKHADPRIQ 30 GYPLMGSPLL 40 MTSILLTYVY 50 FVLSLGPRIM 60 ANRKPFQLRG 70 FMIVYNFSLV 80 ALSLYIVYEF 90 LMSGWLSTYT 100 WRCDPVDYSN 110 SPEALRMVRV 120 AWLFLFSKFI 130 ELMDTVIFIL 140 RKKDGQVTFL 150 HVFHHSVLPW 160 SWWWGVKIAP 170 GGMGSFHAMI 180 NSSVHVIMYL 190 YYGLSAFGPV 200 AQPYLWWKKH 210 MTAIQLIQFV 220 LVSLHISQYY 230 FMSSCNYQYP 240 VIIHLIWMYG 250 TIFFMLFSNF 260 WYHSYTKGKR 270 LPRALQQNGA PGIAKVKAN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Molecular Function GO:0009922 fatty acid elongase activity
Biological Process GO:0036109 alpha-linolenic acid metabolic process
Biological Process GO:0046513 ceramide biosynthetic process
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0034625 fatty acid elongation, monounsaturated fatty acid
Biological Process GO:0034626 fatty acid elongation, polyunsaturated fatty acid
Biological Process GO:0019367 fatty acid elongation, saturated fatty acid
Biological Process GO:0043651 linoleic acid metabolic process
Biological Process GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
Biological Process GO:0030148 sphingolipid biosynthetic process
Biological Process GO:0006636 unsaturated fatty acid biosynthetic process
Biological Process GO:0042761 very long-chain fatty acid biosynthetic process

Reference

PMID: N/A