Search Results
Overview
| Uniprot ID | Q9BW61 |
|---|---|
| Protein Name | DET1- and DDB1-associated protein 1 |
| Gene Name | DDA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | KGLPVYNKSNFSRFH |
| 26 | FHADSVCKASNRRPS |
| 65 | YLHQQWDKKNAAKKR |
| 66 | LHQQWDKKNAAKKRD |
| 70 | WDKKNAAKKRDQEQV |
Function
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28302793, PubMed:28437394, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272)
Protein Sequence
10
MADFLKGLPV
20
YNKSNFSRFH
30
ADSVCKASNR
40
RPSVYLPTRE
50
YPSEQIIVTE
60
KTNILLRYLH
70
QQWDKKNAAK
80
KRDQEQVELE
90
GESSAPPRKV
100
ARTDSPDMHE
DT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0032814 | regulation of natural killer cell activation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.