Overview
| Uniprot ID | Q9BW85 |
|---|
| Protein Name | Splicing factor YJU2 |
|---|
| Gene Name | YJU2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 112 |
TRNFQAEKLLEEEEK |
| 19 |
PPDFDPSKIPKLKLP |
| 243 |
EAPKPKRKVEVWEQS |
| 268 |
SRLVVVKKAKADPDC |
| 270 |
LVVVKKAKADPDCSN |
Function
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453)
Protein Sequence
10
MSERKVLNKY
20
YPPDFDPSKI
30
PKLKLPKDRQ
40
YVVRLMAPFN
50
MRCKTCGEYI
60
YKGKKFNARK
70
ETVQNEVYLG
80
LPIFRFYIKC
90
TRCLAEITFK
100
TDPENTDYTM
110
EHGATRNFQA
120
EKLLEEEEKR
130
VQKEREDEEL
140
NNPMKVLENR
150
TKDSKLEMEV
160
LENLQELKDL
170
NQRQAHVDFE
180
AMLRQHRLSE
190
EERRRQQQEE
200
DEQETAALLE
210
EARKRRLLED
220
SDSEDEAAPS
230
PLQPALRPNP
240
TAILDEAPKP
250
KRKVEVWEQS
260
VGSLGSRPPL
270
SRLVVVKKAK
280
ADPDCSNGQP
290
QAAPTPGAPQ
300
NRKEANPTPL
310
TPGASSLSQL
320
GAYLDSDDSN
GSN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0071006 |
U2-type catalytic step 1 spliceosome |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0000349 |
generation of catalytic spliceosome for first transesterification step |
| Biological Process |
GO:0045292 |
mRNA cis splicing, via spliceosome |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0043518 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.