Search Results
Overview
| Uniprot ID | Q9BW91 |
|---|---|
| Protein Name | ADP-ribose pyrophosphatase |
| Gene Name | NUDT9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | FSPKFNEKDGHVERK |
| 74 | TSPYPGSKVERSQVP |
Function
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate (PubMed:11385575, PubMed:37343711). Has also a weak phosphohydrolase activity against NADH and FAD (in vitro) (PubMed:37343711)
Protein Sequence
10
MAGRLLGKAL
20
AAVSLSLALA
30
SVTIRSSRCR
40
GIQAFRNSFS
50
SSWFHLNTNV
60
MSGSNGSKEN
70
SHNKARTSPY
80
PGSKVERSQV
90
PNEKVGWLVE
100
WQDYKPVEYT
110
AVSVLAGPRW
120
ADPQISESNF
130
SPKFNEKDGH
140
VERKSKNGLY
150
EIENGRPRNP
160
AGRTGLVGRG
170
LLGRWGPNHA
180
ADPIITRWKR
190
DSSGNKIMHP
200
VSGKHILQFV
210
AIKRKDCGEW
220
AIPGGMVDPG
230
EKISATLKRE
240
FGEEALNSLQ
250
KTSAEKREIE
260
EKLHKLFSQD
270
HLVIYKGYVD
280
DPRNTDNAWM
290
ETEAVNYHDE
300
TGEIMDNLML
310
EAGDDAGKVK
320
WVDINDKLKL
330
YASHSQFIKL
340
VAEKRDAHWS
350
EDSEADCHAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0047631 | ADP-ribose diphosphatase activity |
| Molecular Function | GO:0019144 | ADP-sugar diphosphatase activity |
| Biological Process | GO:0055086 | nucleobase-containing small molecule metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.