Search Results
Overview
| Uniprot ID | Q9BWD1 |
|---|---|
| Protein Name | Acetyl-CoA acetyltransferase, cytosolic |
| Gene Name | ACAT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 180 | VSREDQDKVAVLSQN |
| 194 | NRTENAQKAGHFDKE |
| 211 | PVLVSTRKGLIEVKT |
| 266 | AAVVLMKKSEADKRG |
Function
Involved in the biosynthetic pathway of cholesterol
Protein Sequence
10
MNAGSDPVVI
20
VSAARTIIGS
30
FNGALAAVPV
40
QDLGSTVIKE
50
VLKRATVAPE
60
DVSEVIFGHV
70
LAAGCGQNPV
80
RQASVGAGIP
90
YSVPAWSCQM
100
ICGSGLKAVC
110
LAVQSIGIGD
120
SSIVVAGGME
130
NMSKAPHLAY
140
LRTGVKIGEM
150
PLTDSILCDG
160
LTDAFHNCHM
170
GITAENVAKK
180
WQVSREDQDK
190
VAVLSQNRTE
200
NAQKAGHFDK
210
EIVPVLVSTR
220
KGLIEVKTDE
230
FPRHGSNIEA
240
MSKLKPYFLT
250
DGTGTVTPAN
260
ASGINDGAAA
270
VVLMKKSEAD
280
KRGLTPLARI
290
VSWSQVGVEP
300
SIMGIGPIPA
310
IKQAVTKAGW
320
SLEDVDIFEI
330
NEAFAAVSAA
340
IVKELGLNPE
350
KVNIEGGAIA
360
LGHPLGASGC
370
RILVTLLHTL
380
ERMGRSRGVA
390
ALCIGGGMGI
AMCVQRE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0003985 | acetyl-CoA C-acetyltransferase activity |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.