Overview
| Uniprot ID | Q9BWE0 |
|---|
| Protein Name | DNA-binding protein REPIN1 |
|---|
| Gene Name | REPIN1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 210 |
ALEEAAAKALGPRPR |
| 527 |
CDRSFSQKSNLITHR |
Function
Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity)
Protein Sequence
10
MLERRCRGPL
20
AMGLAQPRLL
30
SGPSQESPQT
40
LGKESRGLRQ
50
QGTSVAQSGA
60
QAPGRAHRCA
70
HCRRHFPGWV
80
ALWLHTRRCQ
90
ARLPLPCPEC
100
GRRFRHAPFL
110
ALHRQVHAAA
120
TPDLGFACHL
130
CGQSFRGWVA
140
LVLHLRAHSA
150
AKRPIACPKC
160
ERRFWRRKQL
170
RAHLRRCHPP
180
APEARPFICG
190
NCGRSFAQWD
200
QLVAHKRVHV
210
AEALEEAAAK
220
ALGPRPRGRP
230
AVTAPRPGGD
240
AVDRPFQCAC
250
CGKRFRHKPN
260
LIAHRRVHTG
270
ERPHQCPECG
280
KRFTNKPYLT
290
SHRRIHTGEK
300
PYPCKECGRR
310
FRHKPNLLSH
320
SKIHKRSEGS
330
AQAAPGPGSP
340
QLPAGPQESA
350
AEPTPAVPLK
360
PAQEPPPGAP
370
PEHPQDPIEA
380
PPSLYSCDDC
390
GRSFRLERFL
400
RAHQRQHTGE
410
RPFTCAECGK
420
NFGKKTHLVA
430
HSRVHSGERP
440
FACEECGRRF
450
SQGSHLAAHR
460
RDHAPDRPFV
470
CPDCGKAFRH
480
KPYLAAHRRI
490
HTGEKPYVCP
500
DCGKAFSQKS
510
NLVSHRRIHT
520
GERPYACPDC
530
DRSFSQKSNL
540
ITHRKSHIRD
550
GAFCCAICGQ
560
TFDDEERLLA
HQKKHDV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0043565 |
sequence-specific DNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:2000191 |
regulation of fatty acid transport |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.