Search Results
Overview
| Uniprot ID | Q9BWM7 |
|---|---|
| Protein Name | Sideroflexin-3 |
| Gene Name | SFXN3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 71 | EDQLWRAKYVYDSAF |
Function
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778)
Protein Sequence
10
MGELPLDINI
20
QEPRWDQSTF
30
LGRARHFFTV
40
TDPRNLLLSG
50
AQLEASRNIV
60
QNYRAGVVTP
70
GITEDQLWRA
80
KYVYDSAFHP
90
DTGEKVVLIG
100
RMSAQVPMNM
110
TITGCMLTFY
120
RKTPTVVFWQ
130
WVNQSFNAIV
140
NYSNRSGDTP
150
ITVRQLGTAY
160
VSATTGAVAT
170
ALGLKSLTKH
180
LPPLVGRFVP
190
FAAVAAANCI
200
NIPLMRQREL
210
QVGIPVADEA
220
GQRLGYSVTA
230
AKQGIFQVVI
240
SRICMAIPAM
250
AIPPLIMDTL
260
EKKDFLKRRP
270
WLGAPLQVGL
280
VGFCLVFATP
290
LCCALFPQKS
300
SIHISNLEPE
310
LRAQIHEQNP
320
SVEVVYYNKG
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0015194 | L-serine transmembrane transporter activity |
| Molecular Function | GO:0015075 | monoatomic ion transmembrane transporter activity |
| Molecular Function | GO:0022857 | transmembrane transporter activity |
| Biological Process | GO:1990542 | mitochondrial transmembrane transport |
| Biological Process | GO:0006730 | one-carbon metabolic process |
| Biological Process | GO:0140300 | serine import into mitochondrion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.