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Overview

Uniprot ID	Q9BX26
Protein Name	Synaptonemal complex protein 2
Gene Name	SYCP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
986	KSRSSLEKGQPSSKM
992	EKGQPSSKMTPSKNI

Function

Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements

Protein Sequence

10 MPIRPDLQQL 20 EKCIDDALRK 30 NDFKPLKTLL 40 QIDICEDVKI 50 KCSKQFFHKV 60 DNLICRELNK 70 EDIHNVSAIL 80 VSVGRCGKNI 90 SVLGQAGLLT 100 MIKQGLIQKM 110 VAWFEKSKDI 120 IQSQGNSKDE 130 AVLNMIEDLV 140 DLLLVIHDVS 150 DEGKKQVVES 160 FVPRICSLVI 170 DSRVNICIQQ 180 EIIKKMNAML 190 DKMPQDARKI 200 LSNQEMLILM 210 SSMGERILDA 220 GDYDLQVGIV 230 EALCRMTTEK 240 QRQELAHQWF 250 SMDFIAKAFK 260 RIKDSEFETD 270 CRIFLNLVNG 280 MLGDKRRVFT 290 FPCLSAFLDK 300 YELQIPSDEK 310 LEEFWIDFNL 320 GSQTLSFYIA 330 GDNDDHQWEA 340 VTVPEEKVQI 350 YSIEVRESKK 360 LLTIILKNTV 370 KISKREGKEL 380 LLYFDASLEI 390 TNVTQKIFGA 400 TKHRESIRKQ 410 GISVAKTSLH 420 ILFDASGSQI 430 LVPESQISPV 440 GEELVSLKEK 450 SKSPKEFAKP 460 SKYIKNSDKG 470 NRNNSQLEKT 480 TPSKRKMSEA 490 SMIVSGADRY 500 TMRSPVLFSN 510 TSIPPRRRRI 520 KPPLQMTSSA 530 EKPSVSQTSE 540 NRVDNAASLK 550 SRSSEGRHRR 560 DNIDKHIKTA 570 KCVENTENKN 580 VEFPNQNFSE 590 LQDVIPDSQA 600 AEKRDHTILP 610 GVLDNICGNK 620 IHSKWACWTP 630 VTNIELCNNQ 640 RASTSSGDTL 650 NQDIVINKKL 660 TKQKSSSSIS 670 DHNSEGTGKV 680 KYKKEQTDHI 690 KIDKAEVEVC 700 KKHNQQQNHP 710 KYSGQKNTEN 720 AKQSDWPVES 730 ETTFKSVLLN 740 KTIEESLIYR 750 KKYILSKDVN 760 TATCDKNPSA 770 SKNVQSHRKA 780 EKELTSELNS 790 WDSKQKKMRE 800 KSKGKEFTNV 810 AESLISQINK 820 RYKTKDDIKS 830 TRKLKESLIN 840 SGFSNKPVVQ 850 LSKEKVQKKS 860 YRKLKTTFVN 870 VTSECPVNDV 880 YNFNLNGADD 890 PIIKLGIQEF 900 QATAKEACAD 910 RSIRLVGPRN 920 HDELKSSVKT 930 KDKKIITNHQ 940 KKNLFSDTET 950 EYRCDDSKTD 960 ISWLREPKSK 970 PQLIDYSRNK 980 NVKNHKSGKS 990 RSSLEKGQPS 1000 SKMTPSKNIT 1010 KKMDKTIPEG 1020 RIRLPRKATK 1030 TKKNYKDLSN 1040 SESECEQEFS 1050 HSFKENIPVK 1060 EENIHSRMKT 1070 VKLPKKQQKV 1080 FCAETEKELS 1090 KQWKNSSLLK 1100 DAIRDNCLDL 1110 SPRSLSGSPS 1120 SIEVTRCIEK 1130 ITEKDFTQDY 1140 DCITKSISPY 1150 PKTSSLESLN 1160 SNSGVGGTIK 1170 SPKNNEKNFL 1180 CASESCSPIP 1190 RPLFLPRHTP 1200 TKSNTIVNRK 1210 KISSLVLTQE 1220 TQNSNSYSDV 1230 SSYSSEERFM 1240 EIESPHINEN 1250 YIQSKREESH 1260 LASSLSKSSE 1270 GREKTWFDMP 1280 CDATHVSGPT 1290 QHLSRKRIYI 1300 EDNLSNSNEV 1310 EMEEKGERRA 1320 NLLPKKLCKI 1330 EDADHHIHKM 1340 SESVSSLSTN 1350 DFSIPWETWQ 1360 NEFAGIEMTY 1370 ETYERLNSEF 1380 KRRNNIRHKM 1390 LSYFTTQSWK 1400 TAQQHLRTMN 1410 HQSQDSRIKK 1420 LDKFQFIIIE 1430 ELENFEKDSQ 1440 SLKDLEKEFV 1450 DFWEKIFQKF 1460 SAYQKSEQQR 1470 LHLLKTSLAK 1480 SVFCNTDSEE 1490 TVFTSEMCLM 1500 KEDMKVLQDR 1510 LLKDMLEEEL 1520 LNVRRELMSV 1530 FMSHERNANV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000779	condensed chromosome, centromeric region
Cellular Component	GO:0000794	condensed nuclear chromosome
Cellular Component	GO:0000800	lateral element
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000795	synaptonemal complex
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0007129	homologous chromosome pairing at meiosis
Biological Process	GO:0035825	homologous recombination
Biological Process	GO:0007131	reciprocal meiotic recombination
Biological Process	GO:0007130	synaptonemal complex assembly

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.