Search Results

Overview

Uniprot IDQ9BX63
Protein NameFanconi anemia group J protein
Gene NameBRIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
575 NGLLVLPKNKKRSRQ
577 LLVLPKNKKRSRQKT

Function

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400)

Protein Sequence

10 MSSMWSEYTI 20 GGVKIYFPYK 30 AYPSQLAMMN 40 SILRGLNSKQ 50 HCLLESPTGS 60 GKSLALLCSA 70 LAWQQSLSGK 80 PADEGVSEKA 90 EVQLSCCCAC 100 HSKDFTNNDM 110 NQGTSRHFNY 120 PSTPPSERNG 130 TSSTCQDSPE 140 KTTLAAKLSA 150 KKQASIYRDE 160 NDDFQVEKKR 170 IRPLETTQQI 180 RKRHCFGTEV 190 HNLDAKVDSG 200 KTVKLNSPLE 210 KINSFSPQKP 220 PGHCSRCCCS 230 TKQGNSQESS 240 NTIKKDHTGK 250 SKIPKIYFGT 260 RTHKQIAQIT 270 RELRRTAYSG 280 VPMTILSSRD 290 HTCVHPEVVG 300 NFNRNEKCME 310 LLDGKNGKSC 320 YFYHGVHKIS 330 DQHTLQTFQG 340 MCKAWDIEEL 350 VSLGKKLKAC 360 PYYTARELIQ 370 DADIIFCPYN 380 YLLDAQIRES 390 MDLNLKEQVV 400 ILDEAHNIED 410 CARESASYSV 420 TEVQLRFARD 430 ELDSMVNNNI 440 RKKDHEPLRA 450 VCCSLINWLE 460 ANAEYLVERD 470 YESACKIWSG 480 NEMLLTLHKM 490 GITTATFPIL 500 QGHFSAVLQK 510 EEKISPIYGK 520 EEAREVPVIS 530 ASTQIMLKGL 540 FMVLDYLFRQ 550 NSRFADDYKI 560 AIQQTYSWTN 570 QIDISDKNGL 580 LVLPKNKKRS 590 RQKTAVHVLN 600 FWCLNPAVAF 610 SDINGKVQTI 620 VLTSGTLSPM 630 KSFSSELGVT 640 FTIQLEANHI 650 IKNSQVWVGT 660 IGSGPKGRNL 670 CATFQNTETF 680 EFQDEVGALL 690 LSVCQTVSQG 700 ILCFLPSYKL 710 LEKLKERWLS 720 TGLWHNLELV 730 KTVIVEPQGG 740 EKTNFDELLQ 750 VYYDAIKYKG 760 EKDGALLVAV 770 CRGKVSEGLD 780 FSDDNARAVI 790 TIGIPFPNVK 800 DLQVELKRQY 810 NDHHSKLRGL 820 LPGRQWYEIQ 830 AYRALNQALG 840 RCIRHRNDWG 850 ALILVDDRFR 860 NNPSRYISGL 870 SKWVRQQIQH 880 HSTFESALES 890 LAEFSKKHQK 900 VLNVSIKDRT 910 NIQDNESTLE 920 VTSLKYSTSP 930 YLLEAASHLS 940 PENFVEDEAK 950 ICVQELQCPK 960 IITKNSPLPS 970 SIISRKEKND 980 PVFLEEAGKA 990 EKIVISRSTS 1000 PTFNKQTKRV 1010 SWSSFNSLGQ 1020 YFTGKIPKAT 1030 PELGSSENSA 1040 SSPPRFKTEK 1050 MESKTVLPFT 1060 DKCESSNLTV 1070 NTSFGSCPQS 1080 ETIISSLKID 1090 ATLTRKNHSE 1100 HPLCSEEALD 1110 PDIELSLVSE 1120 EDKQSTSNRD 1130 FETEAEDESI 1140 YFTPELYDPE 1150 DTDEEKNDLA 1160 ETDRGNRLAN 1170 NSDCILAKDL 1180 FEIRTIKEVD 1190 SAREVKAEDC 1200 IDTKLNGILH 1210 IEESKIDDID 1220 GNVKTTWINE 1230 LELGKTHEIE 1240 IKNFKPSPSK NKGMFPGFK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0106300 protein-DNA covalent cross-linking repair
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005657 replication fork
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0043139 5'-3' DNA helicase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003678 DNA helicase activity
Molecular Function GO:0160225 G-quadruplex unwinding activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0000077 DNA damage checkpoint signaling
Biological Process GO:0006281 DNA repair
Biological Process GO:0006302 double-strand break repair
Biological Process GO:1990918 double-strand break repair involved in meiotic recombination
Biological Process GO:0035825 homologous recombination
Biological Process GO:0006289 nucleotide-excision repair

Reference

PMID: N/A