Search Results

Overview

Uniprot IDQ9BX66
Protein NameSorbin and SH3 domain-containing protein 1
Gene NameSORBS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
480 PLSVPRSKSEMSYID
542 IYEYQPGKSSVLTNE
68 LTKICTGKGAVTLRA
709 PSSSASTKDSESPRH
855 ELLPPAEKAQPKKLT

Function

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity)

Protein Sequence

10 MSSECDGGSK 20 AVMNGLAPGS 30 NGQDKATADP 40 LRARSISAVK 50 IIPVKTVKNA 60 SGLVLPTDMD 70 LTKICTGKGA 80 VTLRASSSYR 90 ETPSSSPASP 100 QETRQHESKP 110 GLEPEPSSAD 120 EWRLSSSADA 130 NGNAQPSSLA 140 AKGYRSVHPN 150 LPSDKSQDAT 160 SSSAAQPEVI 170 VVPLYLVNTD 180 RGQEGTARPP 190 TPLGPLGCVP 200 TIPATASAAS 210 PLTFPTLDDF 220 IPPHLQRWPH 230 HSQPARASGS 240 FAPISQTPPS 250 FSPPPPLVPP 260 APEDLRRVSE 270 PDLTGAVSST 280 DSSPLLNEVS 290 SSLIGTDSQA 300 FPSVSKPSSA 310 YPSTTIVNPT 320 IVLLQHNREQ 330 QKRLSSLSDP 340 VSERRVGEQD 350 SAPTQEKPTS 360 PGKAIEKRAK 370 DDSRRVVKST 380 QDLSDVSMDE 390 VGIPLRNTER 400 SKDWYKTMFK 410 QIHKLNRDTP 420 EENPYFPTYK 430 FPELPEIQQT 440 SEEDNPYTPT 450 YQFPASTPSP 460 KSEDDDSDLY 470 SPRYSFSEDT 480 KSPLSVPRSK 490 SEMSYIDGEK 500 VVKRSATLPL 510 PARSSSLKSS 520 SERNDWEPPD 530 KKVDTRKYRA 540 EPKSIYEYQP 550 GKSSVLTNEK 560 MSRDISPEEI 570 DLKNEPWYKF 580 FSELEFGKPP 590 PKKIWDYTPG 600 DCSILPREDR 610 KTNLDKDLSL 620 CQTELEADLE 630 KMETLNKAPS 640 ANVPQSSAIS 650 PTPEISSETP 660 GYIYSSNFHA 670 VKRESDGAPG 680 DLTSLENERQ 690 IYKSVLEGGD 700 IPLQGLSGLK 710 RPSSSASTKD 720 SESPRHFIPA 730 DYLESTEEFI 740 RRRHDDKEKL 750 LADQRRLKRE 760 QEEADIAARR 770 HTGVIPTHHQ 780 FITNERFGDL 790 LNIDDTAKRK 800 SGSEMRPARA 810 KFDFKAQTLK 820 ELPLQKGDIV 830 YIYKQIDQNW 840 YEGEHHGRVG 850 IFPRTYIELL 860 PPAEKAQPKK 870 LTPVQVLEYG 880 EAIAKFNFNG 890 DTQVEMSFRK 900 GERITLLRQV 910 DENWYEGRIP 920 GTSRQGIFPI 930 TYVDVIKRPL 940 VKNPVDYMDL 950 PFSSSPSRSA 960 TASPQFSSHS 970 KLITPAPSSL 980 PHSRRALSPE 990 MHAVTSEWIS 1000 LTVGVPGRRS 1010 LALTPPLPPL 1020 PEASIYNTDH 1030 LALSPRASPS 1040 LSLSLPHLSW 1050 SDRPTPRSVA 1060 SPLALPSPHK 1070 TYSLAPTSQA 1080 SLHMNGDGGV 1090 HTPSSGIHQD 1100 SFLQLPLGSS 1110 DSVISQLSDA 1120 FSSQSKRQPW 1130 REESGQYERK 1140 AERGAGERGP 1150 GGPKISKKSC 1160 LKPSDVVRCL 1170 STEQRLSDLN 1180 TPEESRPGKP 1190 LGSAFPGSEA 1200 EQTERHRGGE 1210 QAGRKAARRG 1220 GSQQPQAQQR 1230 RVTPDRSQTS 1240 QDLFSYQALY 1250 SYIPQNDDEL 1260 ELRDGDIVDV 1270 MEKCDDGWFV 1280 GTSRRTKQFG 1290 TFPGNYVKPL YL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0030055 cell-substrate junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016600 flotillin complex
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0005915 zonula adherens
Molecular Function GO:0003779 actin binding
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0005158 insulin receptor binding
Molecular Function GO:0030159 signaling receptor complex adaptor activity
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0046326 positive regulation of D-glucose import across plasma membrane
Biological Process GO:0045725 positive regulation of glycogen biosynthetic process
Biological Process GO:0046628 positive regulation of insulin receptor signaling pathway
Biological Process GO:0046889 positive regulation of lipid biosynthetic process
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0043149 stress fiber assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.