Search Results
Overview
| Uniprot ID | Q9BX68 |
|---|---|
| Protein Name | Adenosine 5'-monophosphoramidase HINT2 |
| Gene Name | HINT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | LVAKQTAKAEGLGDG |
| 139 | RLVINDGKLGAQSVY |
| 94 | VHFLVIPKKPIPRIS |
Function
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638)
Protein Sequence
10
MAAAVVLAAG
20
LRAARRAVAA
30
TGVRGGQVRG
40
AAGVTDGNEV
50
AKAQQATPGG
60
AAPTIFSRIL
70
DKSLPADILY
80
EDQQCLVFRD
90
VAPQAPVHFL
100
VIPKKPIPRI
110
SQAEEEDQQL
120
LGHLLLVAKQ
130
TAKAEGLGDG
140
YRLVINDGKL
150
GAQSVYHLHI
160
HVLGGRQLQW
PPG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0043530 | adenosine 5'-monophosphoramidase activity |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006694 | steroid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.