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Overview

Uniprot ID	Q9BX69
Protein Name	Caspase recruitment domain-containing protein 6
Gene Name	CARD6
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1032	HHSKAGQKRGGKH**
182	TLSYSVEKVGCEVPA

Function

May be involved in apoptosis

Protein Sequence

10 MATESTPSEI 20 IERERKKLLE 30 ILQHDPDSIL 40 DTLTSRRLIS 50 EEEYETLENV 60 TDLLKKSRKL 70 LILVQKKGEA 80 TCQHFLKCLF 90 STFPQSAAIC 100 GLRHEVLKHE 110 NTVPPQSMGA 120 SSNSEDAFSP 130 GIKQPEAPEI 140 TVFFSEKEHL 150 DLETSEFFRD 160 KKTSYRETAL 170 SARKNEKEYD 180 TPEVTLSYSV 190 EKVGCEVPAT 200 ITYIKDGQRY 210 EELDDSLYLG 220 KEEYLGSVDT 230 PEDAEATVEE 240 EVYDDPEHVG 250 YDGEEDFENS 260 ETTEFSGEEP 270 SYEGSETSLS 280 LEEEQEKSIE 290 ERKKVFKDVL 300 LCLNMDRSRK 310 VLPDFVKQFS 320 LDRGCKWTPE 330 SPGDLAWNFL 340 MKVQARDVTA 350 RDSILSHKVL 360 DEDSKEDLLA 370 GVENLEIRDI 380 QTINPLDVLC 390 ATMLCSDSSL 400 QRQVMSNMYQ 410 CQFALPLLLP 420 DAENNKSILM 430 LGAMKDIVKK 440 QSTQFSGGPT 450 EDTEKFLTLM 460 KMPVISFVRL 470 GYCSFSKSRI 480 LNTLLSPAQL 490 KLHKIFLHQD 500 LPLLVLPRQI 510 SDGLVEITWC 520 FPDSDDRKEN 530 PFFQKPVALA 540 NLRGNLESFW 550 TQFGFLMEVS 560 SAVFFFTDCL 570 GEKEWDLLMF 580 LGEAAIERCY 590 FVLSSQARES 600 EEAQIFQRIL 610 NLKPAQLLFW 620 ERGDAGDRRK 630 NMEGLQAALQ 640 EVMFSSCLRC 650 VSVEDMAALA 660 RELGIQVDED 670 FENTQRIQVS 680 SGENMAGTAE 690 GEGQQRHSQL 700 KSSSKSQALM 710 PIQEPGTQCE 720 LSQNLQNLYG 730 TPVFRPVLEN 740 SWLFPTRIGG 750 NFNHVSLKAS 760 WVMGRPFGSE 770 QRPKWFHPLP 780 FQNAGAQGRG 790 KSFGIQSFHP 800 QIFYSGERFM 810 KFSRVARGCH 820 SNGTFGRLPR 830 PICQHVQACP 840 ERPQMMGTLE 850 RSRAVASKIG 860 HSYSLDSQPA 870 RAVGKPWPQQ 880 ACTRVTELTE 890 ATGKLIRTSH 900 IGKPHPQSFQ 910 PAAATQKLRP 920 ASQQGVQMKT 930 QGGASNPALQ 940 IGSHPMCKSS 950 QFKSDQSNPS 960 TVKHSQPKPF 970 HSVPSQPKSS 980 QTKSCQSQPS 990 QTKPSPCKST 1000 QPKPSQPWPP 1010 QSKPSQPRPP 1020 QPKSSSTNPS 1030 QAKAHHSKAG QKRGGKH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0042981	regulation of apoptotic process

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.