Search Results
Overview
| Uniprot ID | Q9BXB4 |
|---|---|
| Protein Name | Oxysterol-binding protein-related protein 11 |
| Gene Name | OSBPL11 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 169 | GKNNPPLKSRSFSLA |
| 208 | SKLQSLSKRTNLPPD |
Function
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189)
Protein Sequence
10
MQGGEPVSTM
20
KVSESEGKLE
30
GQATAVTPNK
40
NSSCGGGISS
50
SSSSRGGSAK
60
GWQYSDHMEN
70
VYGYLMKYTN
80
LVTGWQYRFF
90
VLNNEAGLLE
100
YFVNEQSRNQ
110
KPRGTLQLAG
120
AVISPSDEDS
130
HTFTVNAASG
140
EQYKLRATDA
150
KERQHWVSRL
160
QICTQHHTEA
170
IGKNNPPLKS
180
RSFSLASSSN
190
SPISQRRPSQ
200
NAISFFNVGH
210
SKLQSLSKRT
220
NLPPDHLVEV
230
REMMSHAEGQ
240
QRDLIRRIEC
250
LPTSGHLSSL
260
DQDLLMLKAT
270
SMATMNCLND
280
CFHILQLQHA
290
SHQKGSLPSG
300
TTIEWLEPKI
310
SLSNHYKNGA
320
DQPFATDQSK
330
PVAVPEEQPV
340
AESGLLAREP
350
EEINADDEIE
360
DTCDHKEDDL
370
GAVEEQRSVI
380
LHLLSQLKLG
390
MDLTRVVLPT
400
FILEKRSLLE
410
MYADFMSHPD
420
LFIAITNGAT
430
AEDRMIRFVE
440
YYLTSFHEGR
450
KGAIAKKPYN
460
PIIGETFHCS
470
WKMPKSEVAS
480
SVFSSSSTQG
490
VTNHAPLSGE
500
SLTQVGSDCY
510
TVRFVAEQVS
520
HHPPVSGFYA
530
ECTERKMCVN
540
AHVWTKSKFL
550
GMSIGVTMVG
560
EGILSLLEHG
570
EEYTFSLPCA
580
YARSILTVPW
590
VELGGKVSVN
600
CAKTGYSASI
610
TFHTKPFYGG
620
KLHRVTAEVK
630
HNITNTVVCR
640
VQGEWNSVLE
650
FTYSNGETKY
660
VDLTKLAVTK
670
KRVRPLEKQD
680
PFESRRLWKN
690
VTDSLRESEI
700
DKATEHKHTL
710
EERQRTEERH
720
RTETGTPWKT
730
KYFIKEGDGW
740
VYHKPLWKII
PTTQPAE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0160258 | endoplasmic reticulum-trans-Golgi network membrane contact site |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:7770015 | intermembrane lipid transporter complex |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0032934 | sterol binding |
| Biological Process | GO:0045444 | fat cell differentiation |
| Biological Process | GO:0120009 | intermembrane lipid transfer |
| Biological Process | GO:0097212 | lysosomal membrane organization |
| Biological Process | GO:0055091 | phospholipid homeostasis |
| Biological Process | GO:0006649 | phospholipid transfer to membrane |
| Biological Process | GO:0070328 | triglyceride homeostasis |
Reference
PMID: N/A