Search Results

Overview

Uniprot IDQ9BXF3
Protein NameChromatin remodeling regulator CECR2
Gene NameCECR2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
209 GRPPKRKKLQEEILL

Function

Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:15640247, PubMed:22464331, PubMed:26365797, PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (PubMed:28801535). Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:22464331, PubMed:26365797). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465)

Protein Sequence

10 MCPEEGGAAG 20 LGELRSWWEV 30 PAIAHFCSLF 40 RTAFRLPDFE 50 IEELEAALHR 60 DDVEFISDLI 70 ACLLQGCYQR 80 RDITPQTFHS 90 YLEDIINYRW 100 ELEEGKPNPL 110 REASFQDLPL 120 RTRVEILHRL 130 CDYRLDADDV 140 FDLLKGLDAD 150 SLRVEPLGED 160 NSGALYWYFY 170 GTRMYKEDPV 180 QGKSNGELSL 190 SRESEGQKNV 200 SSIPGKTGKR 210 RGRPPKRKKL 220 QEEILLSEKQ 230 EENSLASEPQ 240 TRHGSQGPGQ 250 GTWWLLCQTE 260 EEWRQVTESF 270 RERTSLRERQ 280 LYKLLSEDFL 290 PEICNMIAQK 300 GKRPQRTKAE 310 LHPRWMSDHL 320 SIKPVKQEET 330 PVLTRIEKQK 340 RKEEEEERQI 350 LLAVQKKEQE 360 QMLKEERKRE 370 LEEKVKAVEG 380 MCSVRVVWRG 390 ACLSTSRPVD 400 RAKRRKLREE 410 RAWLLAQGKE 420 LPPELSHLDP 430 NSPMREEKKT 440 KDLFELDDDF 450 TAMYKVLDVV 460 KAHKDSWPFL 470 EPVDESYAPN 480 YYQIIKAPMD 490 ISSMEKKLNG 500 GLYCTKEEFV 510 NDMKTMFRNC 520 RKYNGESSEY 530 TKMSDNLERC 540 FHRAMMKHFP 550 GEDGDTDEEF 560 WIREDEKREK 570 RRSRAGRSGG 580 SHVWTRSRDP 590 EGSSRKQQPM 600 ENGGKSLPPT 610 RRAPSSGDDQ 620 SSSSTQPPRE 630 VGTSNGRGFS 640 HPLHCGGTPS 650 QAPFLNQMRP 660 AVPGTFGPLR 670 GSDPATLYGS 680 SGVPEPHPGE 690 PVQQRQPFTM 700 QPPVGINSLR 710 GPRLGTPEEK 720 QMCGGLTHLS 730 NMGPHPGSLQ 740 LGQISGPSQD 750 GSMYAPAQFQ 760 PGFIPPRHGG 770 APARPPDFPE 780 SSEIPPSHMY 790 RSYKYLNRVH 800 SAVWNGNHGA 810 TNQGPLGPDE 820 KPHLGPGPSH 830 QPRTLGHVMD 840 SRVMRPPVPP 850 NQWTEQSGFL 860 PHGVPSSGYM 870 RPPCKSAGHR 880 LQPPPVPAPS 890 SLFGAPAQAL 900 RGVQGGDSMM 910 DSPEMIAMQQ 920 LSSRVCPPGV 930 PYHPHQPAHP 940 RLPGPFPQVA 950 HPMSVTVSAP 960 KPALGNPGRA 970 PENSEAQEPE 980 NDQAEPLPGL 990 EEKPPGVGTS 1000 EGVYLTQLPH 1010 PTPPLQTDCT 1020 RQSSPQERET 1030 VGPELKSSSS 1040 ESADNCKAMK 1050 GKNPWPSDSS 1060 YPGPAAQGCV 1070 RDLSTVADRG 1080 ALSENGVIGE 1090 ASPCGSEGKG 1100 LGSSGSEKLL 1110 CPRGRTLQET 1120 MPCTGQNAAT 1130 PPSTDPGLTG 1140 GTVSQFPPLY 1150 MPGLEYPNSA 1160 AHYHISPGLQ 1170 GVGPVMGGKS 1180 PASHPQHFPP 1190 RGFQSNHPHS 1200 GGFPRYRPPQ 1210 GMRYSYHPPP 1220 QPSYHHYQRT 1230 PYYACPQSFS 1240 DWQRPLHPQG 1250 SPSGPPASQP 1260 PPPRSLFSDK 1270 NAMASLQGCE 1280 TLNAALTSPT 1290 RMDAVAAKVP 1300 NDGQNPGPEE 1310 EKLDESMERP 1320 ESPKEFLDLD 1330 NHNAATKRQS 1340 SLSASEYLYG 1350 TPPPLSSGMG 1360 FGSSAFPPHS 1370 VMLQTGPPYT 1380 PQRPASHFQP 1390 RAYSSPVAAL 1400 PPHHPGATQP 1410 NGLSQEGPIY 1420 RCQEEGLGHF 1430 QAVMMEQIGT 1440 RSGIRGPFQE 1450 MYRPSGMQMH 1460 PVQSQASFPK 1470 TPTAATSQEE 1480 VPPHKPPTLP LDQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0090537 CERF complex
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process GO:0006309 apoptotic DNA fragmentation
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0061640 cytoskeleton-dependent cytokinesis
Biological Process GO:0097194 execution phase of apoptosis
Biological Process GO:0007338 single fertilization
Biological Process GO:0016192 vesicle-mediated transport

Reference

PMID: N/A